My guess would be Esto, which is about 934 miles from Detroit according to Google maps.
The closest Tennessee city to Florida would be Chattanooga, TN.
The closest major city in Florida to the Virgin Islands is Miami. However, the closest Florida city of any size to the Virgin Islands is probably Key West, Florida.
it is closest to Beijing
The driving distance from Detroit, Michigan to Panama City, Florida is about 1,002 miles.
Orlando, Florida!
the mark city
In Florida the Park is Called Disney World as it is a sort of city in and of itself. But the closest city is Orlando.
No Mexican city is near Florida. Mexico is on the Gulf of Mexico and on the Gulf you will find New Orleans, and Corpus Cristi Texas as the nearest to Mexico. Florida is closest to Havana Cuba.
The closest major airport to Panama City, Florida is Northwest Florida Beaches International Airport (ECP / KECP). This airport is in Panama City Beach, Florida and is about 15 miles from the center of Panama City, FL.
Miami
The closest major city to the intersection of Interstate 10 & Interstate 75 is Lake City, Florida.
It is 988 miles from Detroit, Michigan, to Panama City Beach, Florida. This is about 15 hours and 5 minutes driving in the car.