1. Glycolysis is anabolic pathway but Gluconeogenesis is catabolic patway
2. Glycolysis produce net 2ATP but Gluconeogenesis consume net 6ATP per glucose molecule
3. Glycolysis catabolizing sugars/polysaccharides but Gluconeogenesis synthesizing sugars/polysachharides
4. In Glycolysis, Glucose is Substrate & Pyruvate is By-Product but in Gluconeogenesis is vice versa
By-Helmi Zolkeflay
Glycolysis is the breakdown of glucose into pyruvate, generating ATP and NADH, while gluconeogenesis is the synthesis of glucose from non-carbohydrate precursors such as amino acids, lactate, or glycerol. Glycolysis is a catabolic process, whereas gluconeogenesis is an anabolic process that occurs mainly in the liver and kidneys to maintain blood glucose levels during fasting or low carbohydrate intake.
In glycolysis you get pyruvate (or lactate) as a end product but in gluconeogenesis you get glucose formed from either Fat or Proteins. There are many intermediate steps before pyruvate is formed from Proteins and Fats. So gluconeogenesis cannot be considered as reversal of glycolysis.
"start gluconeogenesis and glycolysis in hepatocytes!"
Glycolysis and gluconeogenesis occurring simultaneously.
Anaerobic glycolysis produces lactate, aerobic glycolysis produces pyruvate.
Nothing, pyruvic acid is the primary substrate used in gluconeogenesis or reverse glycolysis.
pyruvate carboxylase and phosphoenolpyruvate carboxykinase (PEPCK)
gluconeogenesis
A NAD is an electron carrier involved in glycolysis and NADH is a hydrogen carrier involved in glycolysis.
The Cori cycle is metabolic interaction between the liver and muscle tissue. gluconeogenesis is occurring in the liver while glycolysis is happening in the muscle tissue. The two fates of the glucose undergoing glycolysis in the muscle tissue is ultimate breakdown into lactate and alanine.
Fermentation is anaerobic respiration. Glycolysis is part of aerobic respiration. The pathways for both processes, however, are almost identical to each other.
Gluconeogenesis
Anaerobic does not need oxygen to occur, aerobic does. Both pathways start with the process of glycolysis.