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1. Glycolysis is anabolic pathway but Gluconeogenesis is catabolic patway

2. Glycolysis produce net 2ATP but Gluconeogenesis consume net 6ATP per glucose molecule

3. Glycolysis catabolizing sugars/polysaccharides but Gluconeogenesis synthesizing sugars/polysachharides

4. In Glycolysis, Glucose is Substrate & Pyruvate is By-Product but in Gluconeogenesis is vice versa

By-Helmi Zolkeflay

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11y ago
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1mo ago

Glycolysis is the breakdown of glucose into pyruvate, generating ATP and NADH, while gluconeogenesis is the synthesis of glucose from non-carbohydrate precursors such as amino acids, lactate, or glycerol. Glycolysis is a catabolic process, whereas gluconeogenesis is an anabolic process that occurs mainly in the liver and kidneys to maintain blood glucose levels during fasting or low carbohydrate intake.

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Q: What is the difference between glycolysis and gluconeogenesis?
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Why gluconeogenesis cannot be considered a reversal of glycolysis even though both pathways share reversible reactions?

In glycolysis you get pyruvate (or lactate) as a end product but in gluconeogenesis you get glucose formed from either Fat or Proteins. There are many intermediate steps before pyruvate is formed from Proteins and Fats. So gluconeogenesis cannot be considered as reversal of glycolysis.


What message does insulin take to the liver?

"start gluconeogenesis and glycolysis in hepatocytes!"


Which of the following is an example of futile cycling?

Glycolysis and gluconeogenesis occurring simultaneously.


The difference between aerobic and anaerobic glycolysis is?

Anaerobic glycolysis produces lactate, aerobic glycolysis produces pyruvate.


Is there a pyruvate produced in glycolsis?

Nothing, pyruvic acid is the primary substrate used in gluconeogenesis or reverse glycolysis.


Which enzyme(s) bypass the pyruvate kinase reaction of glycolysis in gluconeogenesis?

pyruvate carboxylase and phosphoenolpyruvate carboxykinase (PEPCK)


The process in which glucose is converted to two three-carbon organic molecules and energy is released is called?

gluconeogenesis


What is the difference between NAD and NADH?

A NAD is an electron carrier involved in glycolysis and NADH is a hydrogen carrier involved in glycolysis.


Two regions of cori cycle and two fates of the glucose?

The Cori cycle is metabolic interaction between the liver and muscle tissue. gluconeogenesis is occurring in the liver while glycolysis is happening in the muscle tissue. The two fates of the glucose undergoing glycolysis in the muscle tissue is ultimate breakdown into lactate and alanine.


What is difference between glycolysis and fermentation?

Fermentation is anaerobic respiration. Glycolysis is part of aerobic respiration. The pathways for both processes, however, are almost identical to each other.


What is the formation of glucose from proteins and fats?

Gluconeogenesis


Difference between the two types of respiration?

Anaerobic does not need oxygen to occur, aerobic does. Both pathways start with the process of glycolysis.