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First, as the terms suggest, bbb separates blood from brain matter while bcb separates blood from csf in the ventricles and sub-arachinoid spaces in the cns.

But the paramount difference is int the permeability of the bcb and the almost perfect impermeability of bbb due to the tight juncttions between the aatrocytes that protect the brain

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Q: What is the difference between the blood brain barrier and the blood cerebrospinal fluid barrier?
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