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I consider the concept of Zero as a had a profound influence on mathematics. This concept comes to us from ancient India, via the Arabs. Literally 'leave a space' and in the script of the time, pronounced as siff (?). [From which we derive cipher!]

Fibonacci introduced the concept to Italy, and hence Europe around 1200+/- A.D.

Other contributors would have different answers.

The same scholar, Pingala, in the 2nd century AD, also developed or records a binary method of counting.

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