The Fertile Crescent, formed by Mesopotamia, the Levant and the Nile valley.
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He did not circle the sea, he operated in the eastern part only.
The Greeks colonized much of the Eastern Mediterranean, southern Italy, and in the times of Alexander the Great, much of the Middle East and his empire.
Alexander the Great conquered the eastern Mediterranean from Greece to and including Egypt, and also parts of northwest India.
Alexander the great was significant because he conquered much of the "eastern known world" of the day and, while his empire didn't survive him, the Hellenistic influences he seeded throughout the region did last and influenced the civilizations of the region.
The so called 'fertile crescent'
The lush region that forms a great arc from the Nile River to the eastern shore of the Mediterranean Sea to the Persian Gulf is the Fertile Crescent. It was largely responsible for the area's status as the 'cradle of civilization.'
The region under his control in the Eastern Mediterranean was given a veneer of Greek culture and civilisation. This affected only the upper classes - the rest went on with their normal culture.
That is the fertile crescent
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Eastern Africa
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fertile crescent
Eastern Europe is a cultural crossroads, or a place where various cultures cross paths. Another answer: The answer could be almost any region of Europe. Traditionally, the Mediterranean areas of Europe were considered in this light.
Firstly its success in the Western Mediterranean against Carthage, then in progressively gaining dominance in the Eastern Mediterranean. Its great strengths were its military dominance and its ability of governance by promoting stable local self-governance under Roman provincial direction and military peacekeeping and defence against external intrusions.
The Phoenicians were a Semitic people who settled in the Levant (eastern Mediterranean coast). They became great traders, and as their civilisation developed, invented the alphabet which formed the basis of Greek, Roman and today's alphabetical writings.
Eastern Time