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Should never take more than 16mg at a time, and only take that amount if you have been taking other high doses of opiates for an extended period of time. Even then suboxone should not be taken until all opiates are completely out of your system or you risk getting VERY sick, trust me on this. Wait at least 12 hours before taking suboxone after your last use of an opiate, unless it is methadone in that case you will need to wait at least 48 hours. The antagonist you speak of is called naloxone, which is also know as narcan and is used to treat overdose of opiates. But when suboxone is taken sublingually(under your tongue) most of the naloxone is rendered inactive. It is mainly in there to keep people from "shooting up" the suboxone. Bupremorphine is active ingredient in suboxone and is a semi-synthetic opiate itself. That is what take away the withdrawal symptoms. Message me if you have any other questions about Suboxone.

UPDATE!!-- Bruce5890

Dosing higher then 16mg is ok. I believe the maximum dose before the naloxone starts working is 32mg. I know this is true because my doctor asked if I needed a higher dose and I am already at 24mg and sometimes takes 32.

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Q: What is the max dose of suboxone until the antagonist kicks in?
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