What is the most direct route from Buffalo NY to Lexington KY?
- Take I-90 WEST on the New York State Thruway (toll road) to Pennsylvania where I-90 becomes toll-free.
- Take I-90 WEST in Pennsylvania to I-79 SOUTH to PITTSBURGH at EXIT 22A.
- Take I-79 SOUTH to I-64 WEST in Charleston, West Virginia. Follow signs.
- Take I-64 WEST to Lexington.