What is the most direct route from Buffalo NY to Lexington KY?

  1. Take I-90 WEST on the New York State Thruway (toll road) to Pennsylvania where I-90 becomes toll-free.
  2. Take I-90 WEST in Pennsylvania to I-79 SOUTH to PITTSBURGH at EXIT 22A.
  3. Take I-79 SOUTH to I-64 WEST in Charleston, West Virginia. Follow signs.
  4. Take I-64 WEST to Lexington.