The enzymes in the pancreas (which include several proteases, several nucleases, several elastases, pancreatic amylase, carboxypeptidase and steapsin) need to be of an alkaline pH (about pH8) to cancel out the highly acidic produce of the stomach. The pancreatic juices meet the bolus in the duodenum of the small intestine.
Optimum pH of most enzymes is 7. Optimum pH is pH at which enzyme shows maximum activity . It all depends to the particular enzyme you are talking about, there is no general rule. for example in human pepsin catalyse the reaction at high acidic pH (1.5 to 3) whereas trypsin has optimum pH falls between 7 to 9 (neutral to basic).
Every enzyme works at its maximum rate at a specific temprature called as optimum temprature for that enzyme. AND all enzymes work at their maximum rate at narrow range of pH, called as optimum pH. A slight increase or decrease in pH causes the retardation in enzyme activity or blocks it completely.
every enzyme has specific optimum temperatures and pH. 1. The pH is very specific even a minor change of .5 will cause the enzyme to denature. 2. The temperature is less specific all enzymes will work below the optimum temperature but the reaction will be slower. Above the optimum temperature the enzyme will denature. Note the optimum temperature of the human body is around 37.5 degrees C and the optimum pH is around 7.3.
Every enzyme has an optimum temperature and pH, at which it has the best or "optimum"activity. So any change in temperature and pH will lead to inactivation of the enzyme. Since most enzymes are protein in nature, temperatures higher than the optimum for the particular enzyme (every enzyme has its own unique and specific optimum pH and temperature) can lead to denaturation of the proteinaceous enzyme. Similarly, too much of a change in pH (higher…