pKa1 = 2.16
pKa2 = 8.05
Ref: Newton, D.W., Murray, w.j., Lovell, M.W. pKa Determination of benzhydrylpiperazine antihistamines in aqueous and aqueous methanol solutions (1982) Journal of Pharmaceutical Scienses 71 (12), pp. 1363-1366
can you take cyclizine hydrochloride when pregnant?
pKa=40
how do you calculate pKa
Cyclizine is used for motion sickness and vomiting. It is taken 30 minutes before departure and can be repeated every four to six hours as needed.
pKa=2.86
pKa = 15
It is around pKa=13
Doxofylline Pka value is about 9.8.
pKa (dissociation constant) is variable with temperature.
the only difference i found was that meclizine is not given to < 12 year old, only to 12 and older. cyclizine is given to age 6-12 and not <6 years old.
The pka of a protonated ether (the conjugate acid) is about -3.5
The pKa of sulfonic acid is < 0