Levodopa is a drug that helps to supplement dopamine, a neurotransmitter, to the brain of persons with PD.
The effects of dopamine on the brain can be mimicked by the drug levodopa: levodopa therapy is the mainstay of PD treatment in its early stages.
Side effects of DAs are similar to those of levodopa, including drowsiness and confusion. DAs may cause dyskinesias in at least 50% of patients.
The patient will require a short hospital stay.the patient meets several times with the neurologist to adjust the stimulation.The patient's medications are adjusted after surgery, with a reduction in levodopa likely.
Some medications may be affected by B vitamin supplementation, including those prescribed for high blood pressure; Parkinson's disease (such as levodopa, which is inactivated by pantothenic acid); and epileptiform conditions.
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pyridoxine (vitamin B6) can decrease the effect of levodopa.
Levodopa itself is not well tolerated, which is why it is combined with carbidopa. Carbidopa decreases peripheral metabolism of levodopa, which allows for lower doses of levodopa and less-severe side effects.
Although levodopa can cross our BBB, but it will be decarboxylated to dopamine peripherally before reaching our CNS - only small amount of Levodopa will be left and available to pass our BBB.So, instead of giving levodopa in high dose (which can cause lots of side effects), we give levodopa with peripheral decarboxylase inhibitors (e.g. carbidopa, benserazide) which can inhibit decarboxylation of levodopa in GIT and peripheral tissues. (By combining levodopa and peripheral decarobxylase inhibitors, we will have less side effects too)
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This may occur after five to 10 years or more of successful levodopa treatment.
Early on in PD, symptoms can be effectively treated with medication, especially levodopa and the dopamine agonists (drugs that act like levodopa).
The effects of dopamine on the brain can be mimicked by the drug levodopa: levodopa therapy is the mainstay of PD treatment in its early stages.
Bromocriptine (dopaminergic agonist drug) has longer duration of action than levodopa (dopamine precursor).
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