Of course, there can be many outcomes from no problems to sickle cell disease to fetal death. Some mutations really cause no problems, some can cause a disease and some are so damaging it can cause the death of the unborn child.
The proteins in the amino-acids might have been responsible for the change in the hemoglobin between gorillas and humans.
A mutation that causes the code for the wrong amino acid (apexvs.com)
no
It is neutral mutation. Codons are made up of 3 base pairs. This gives 64 different combinations, but there are only 20 amino acids, so some different codons will code for the same amino acid. When the base pair that is changed doesn't cause a change in the amino acid it codes for, then ultimately nothing happens
one amino acid in the sequence would change
no
sickle cell disease
Hemoglobin is a protein, which is composed of linked amino acids.
loss of only one amino acid from the normal hemoglobin molecule
The proteins in the amino-acids might have been responsible for the change in the hemoglobin between gorillas and humans.
Sickle cell
There are 9 differences
17 amino acid differences
Yes, it already has by changing the amino acid you have a mutation. That one amino acid counld be in the active site of an enzyme and that one amino acid being changed could result in loss of function or reduction in function of the enzyme. Sickle cell animea is caused by a single such amino acid substiution.
Sickle-cell anemia
Glutamate is substituted for a valine at position 6. But this is not an amino acid problem, it's the construction of hemoglobin that's in error.
Sickle cell hemoglobin differs from normal hemoglobin due to a mutation in the gene that codes for the hemoglobin protein. This mutation leads to the production of an abnormal hemoglobin variant (HbS) that causes red blood cells to become sickle-shaped, leading to various complications such as blockages in blood vessels and reduced oxygen delivery to tissues.