Possibly blown / damaged oil filter o-ring
You might use them while driving and cause a wreck.
could be the timing belt
check the wheel bearing
It might be a broken motor mount or transmission mount.
When it dies, is it a sudden stall, or does it run rough, and then die? If its sudden, it is most likely a electrical problem, but if it runs rough, or dies when accelerating, it might be mechanical. Such as the fuel lines, carb, etc.
it might be a safety thing
Your transmission might automatically shift out of overdrive while driving on the interstate because of low transmission fluid. This issue might also occur because of a bad transmission sensor or overdrive sensor.
Your check engine light will be on and you will feel bucking or jerking while you are accelerating. You will also have an idle surging, sudden stalling of the engine, and a sudden surge in speed while driving on the highway.
What would cause my VW golf to cut out whist driving
If it simply dies without hesitating, I'd guess your crank sensor.
A bad tire can cause your 2002 Honda Civic to jerk while driving. A bad ball joint can also cause this issue.
If you have low air in your tire it might cause your car to shake, also if you don't put air in your tires it may cause it to explode while your driving, It could also be caused by your alignment being off.