Pyruvate dehydrogenase (PDH) are regulated by pyruvate dehydrogenase kinase (PDH-K) and PDH phosphatase. PDH-K effect on PDH is that it will inactivate PDH and PDH phosphatase will reactivate PDH.
PDH-K is regulated by energy surpluses (ATP, NADH) and energy deficits (ADP, NAD). So when there is an energy surplus, PDH-K will inhibit PDH, and vice versa.
PDH phosphatase will activate PDH and is upregulated by magnesium and calcium.
Pyruvate dehydrogenase complex react with pyruvate to form acetyl-CoA
There are very many enzymes involved. A few from glycolysis are: hexokinase and glucokinase, phosphohexose isomerase, phosphofructokinase, pyruvate kinase; from pyruvate decarboxylation are pyruvate dehydrogenase phosphatase and pyruvate dehydrogenase kinase; and a few from the Kreb's cycle are: aconitase, alpha-ketoglutamate dehydrogenase, succinate thiokinase, and fumarase.
Mitochondria
alpha-ketoglutarate dehydrogenase is most similar to pyruvate dehydrogenase as both are enzyme complexes made of 3 units
in cyptoplasm of the prokaryotic cell
Pyruvate dehydrogenase complex react with pyruvate to form acetyl-CoA
There are very many enzymes involved. A few from glycolysis are: hexokinase and glucokinase, phosphohexose isomerase, phosphofructokinase, pyruvate kinase; from pyruvate decarboxylation are pyruvate dehydrogenase phosphatase and pyruvate dehydrogenase kinase; and a few from the Kreb's cycle are: aconitase, alpha-ketoglutamate dehydrogenase, succinate thiokinase, and fumarase.
Pyruvate dehydrogenase
Mitochondria
Pyruvate dehydrogenase complex
dehydrogenase is an enzyme which transfers hydrogen ions from a substrate to an activator.Example are activators are NAD+ and FAD+.
alpha-ketoglutarate dehydrogenase is most similar to pyruvate dehydrogenase as both are enzyme complexes made of 3 units
in cyptoplasm of the prokaryotic cell
Pyruvate dehydrogenase complex
Correct answer: I, II, III and IV
Thiamin, niacin, and riboflavin
Thiamine pyrophosphate (TPP)