You can take the Uptown B-D-F-M (the orange line) from Broadway-Lafayette Street (at Houston Street) to West 4th Street.
Transfer at West 4th Street to the Uptown A-C-E (the blue line) to 34th Street-Penn Station.
Note that the Broadway-Lafayette Station is technically located at Houston Street between Broadway and Crosby Street, not Broadway and Lafayette Street. Crosby Street runs between Broadway and Lafayette Streets, but the station is called the Broadway-Lafayette Station because both Broadway and Lafayette are major streets, while Crosby is a minor street.
If you are coming from further south on Lafayette Street, then take the Uptown N, R or Q trains (of the N-R-Q-W, the yellow line) from the Canal Street Station (at Centre Street, which is one block east of Lafayette Street) to 42nd Street-Times Square.
Transfer at Times Square to the Downtown 1-2-3 (the red line) one stop to 34th Street-Penn Station.
The address 210 Lafayette Street is between Spring and Broome Streets. The closest subway stations are the:
6 train (of the 4-5-6, the dark green line) to Spring Street (at Lafayette Street),
B-D-F-M (the orange line) to Broadway-Lafayette (at Houston Street),
N or R trains (of the N-R-Q, the yellow line) to Prince Street (at Broadway),
Q train to Canal Street (at Lafayette Street).
J-Z (the brown line) to the Bowery (at Kenmare/Delancey Street),
A-C-E to Canal Street (at 6th Avenue),
1 train (of the 1-2-3, the red line) to Canal Street (at Varick Street).
Which train to take depends on where you're coming from.
You can take the Downtown A-C-E (the blue line) from 34th Street-Penn Station to West 4th Street, then transfer at West 4th to the Downtown B-D-F-M (the orange line) to Broadway-Lafayette Street (at Houston Street).If you are going further south on Lafayette Street (around the City Hall area), then take the Uptown 1-2-3 (the red line) one stop, from 34th Street-Penn Station to 42nd Street-Times Square. Then transfer at Times Square to the Downtown N, R or Q trains (of the N-R-Q-W, the yellow line) to Canal Street (at Centre Street, which is one block east of Lafayette Street).
You can take the Downtown A-C-E (the blue line) from 34th Street-Penn Station to West 4th Street, then transfer at West 4th to the Downtown B-D-F-M (the orange line) to Broadway-Lafayette Street (at Houston Street).If you are going further south on Lafayette Street (around the City Hall area), then take the Uptown 1-2-3 (the red line) one stop, from 34th Street-Penn Station to 42nd Street-Times Square. Then transfer at Times Square to the Downtown N, R or Q trains (of the N-R-Q-W, the yellow line) to Canal Street (at Centre Street, which is one block east of Lafayette Street).
No, the AirTrain takes you to and from the subway, and the subway takes you to and from Penn Station. Take the AirTrain to the Howard Beach Station, and get the Manhattan-bound A train (of the A-C-E, the blue line) to 34th Street-Penn Station.
Take the Downtown 2 or 3 trains (of the 1-2-3, the red line) from 34th Street-Penn Station to Wall Street (at William Street).
Yes, the A express train goes from Penn Station to Chambers Street. It's 4 stops (unless you are traveling at night, when the A runs local). The Chambers Street station on the A and C trains is at Church Street.
Take the Uptown E train (of the A-C-E, the blue line) from 34th Street-Penn Station to Court Square.
You don't need to take the subway to get from Penn Station to 28th Street and 8th Avenue (which is in the Chelsea neighborhood, by the way, not in Greenwich Village or Greenwich Connecticut). Penn Station is at 34th Street between 8th and 7th Avenues. So you can just walk there.
Take the Uptown 1-2-3 (the red line) from 34th Street-Penn Station to 42nd Street-Times Square, and transfer there to the N.
Penn Station is at 34th Street so it is 20 blocks away from 54th St. You would take the subway two stops north.
It depends where on Mulberry Street you want to be. There are plenty of cabs at Penn Station that can take you.To take the subway, take the Downtown A-C-E (the blue line) from 34th Street-Penn Station to West 4th Street.If you're going to the north end of Mulberry Street (close to Houston Street) you can transfer at West 4th to the Downtown B-D-F-M (the orange line) to Broadway-Lafayette (at Houston Street), then walk 2 blocks east to Mulberry Street.Or, you can transfer to the Downtown B or D to Grand Street (at Chrystie Street). This will drop you off 5 blocks further south than the Broadway-Lafayette station, 4 blocks east of Mulberry Street.
Take the Downtown 1 train (of the 1-2-3, the red line), 1 stop, from 34th Street-Penn Station to 28th Street (at 7th Avenue).
The A train (of the A-C-E, the blue line). Take the Downtown A train from 175th Street to 34th Street-Penn Station. Entrance to the 175th Street station is included inside the bus terminal complex.