This is an odd question because most people consider the hypothalamus to be the master regulator of the body. While the hypothalamus is itself regulated by feedback mechanisms and descending control pathways from the brain (especially the limbic system), one doesn't often speak of regulating the hypothalamus.
The hypothalamus of normal healthy individuals is constantly working to maintain homeostasis, requiring the constant regulation of many organs and organ systems. It does this by secreting hormones and releasing neurotransmitters, small chemicals that transmit messages between nerve cells. Normal healthy individuals do not require supplementation in order to achieve a healthy, functioning hypothalamus.