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The no 1 reason for a loss of pressure would be the fuel pump, however in order to rule out the injectors, remove the line from the injectors and test the pressure from the line. If the pressure drops, it's the pump, if not, check the injectors for major failure. Either one or all could be the cause. It's best to try to isolate sides if possible but that might take major Plumbing work.

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Q: What would cause a 1993 Ford E 250 6 Cylinder 4.9 Liter to lose fuel pressure assuming there are no leaks in the fuel line?
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