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Oddly enough, the compound microscope was invented before the single lens microscope. But the instruments were not very good to start with and much more could be seen with very small lenses of short focal length.

In about 1597 two Dutch eyeglass makers, Zaccharias Janssen and his son Hans were experimenting with lenses in a tube. They observed that nearby objects viewed through two lenses in line were magnified. Their device was the first compound microscope. However, their lenses were rather large and the magnification obtained was only about 10X.

Galileo also designed a compound microscope, but it was only useful for reflected light. Robert Hooke built the first useable British compound microscope in about 1655.

The single lens microscopes made by a Dutch amateur lens grinder Antonie van Leeuwenhoek were far superior to the early compound instruments. Van Leeuwenhoek, in about 1670,developed a method for grinding very small glass lenses. They were tiny, of the order of a millimeter in diameter, and could magnify several hundred times. Mounted in a brass plate these lenses could use transmitted light to image objects in a drop of water on the end of a metal pin. Screws were used to move the pin and focus the specimen. Van Leeuwenhoek was probably influenced by Robert Hooke's Micrographia (1665) which he might have seen when he visited London in about 1668. Amongst his vast number of discoveries were bacteria, sperm, blood cells and a myriad of protozoa. He also laid the foundations of plant anatomy. His discoveries were reported to the Royal Society in a series of famous letters. Van Leeuwenhoek made hundreds of microscopes over the years and many people copied them, including Hooke himself. Nine of van Leeuwenhoek's original microscopes still exist today.

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Q: When was the first compound microscope finished?
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