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The greatest military disaster suffered by the colonists in the Revolutionary War was that of Camden.

The battle was fought on August 15 and 18, 1780, between the American Army of 3,000 men, led by General Horatio Gates and the British Army of 2,236 men, led by General Lord Cornwallis. The losses were: 650 killed or wounded among the Continentals and 100 killed or wounded and 300 captured among the Militia. The British casualties were 324. Another 150 Americans were killed and 300 taken prisoners, on October 18th, when the retreating Americans were surprised by Tarleton's British Cavalry.

The defeat opened the gate to the British invasion of North Carolina.

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Q: Where did the colonists suffer their biggest loss during the Revolutionary War?
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