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What enzyme catalyze the phosphorylation of glucose after a meal?
glucokinase
What enzyme phosphorylates 90% of the glucose in the liver?
glucokinase
What enzyme converts the glucose into bigger molecules?
The enzyme responsible for converting glucose into larger molecules is called glucokinase. Glucokinase helps to phosphorylate glucose in the first step of glycolysis, ultimately leading to the formation of larger molecules such as glycogen or fatty acids.
Which has a higher Vmax: glucokinase or hexokinase?
Glucokinase
Why is glucokinase inactive in the nucleus?
Glucokinase Regulatory Protein is found in the nucleus which binds glucokinase to inactive it
What are glucokinase deficiency?
Glucokinase deficiency is a rare genetic disorder that affects the enzyme glucokinase, which plays a crucial role in glucose metabolism by facilitating the conversion of glucose to glucose-6-phosphate in the liver and pancreas. This deficiency leads to impaired insulin secretion and results in a form of diabetes known as maturity-onset diabetes of the young (MODY). Patients may experience episodes of hyperglycemia and hypoglycemia, particularly during fasting or illness, due to the enzyme's inability to effectively regulate blood sugar levels. Management typically involves dietary modifications and monitoring blood glucose levels.
What substrate is converted into glucose 6 phosphate by the enzyme hexokinase?
Glucose is the substrate that is converted into glucose 6-phosphate by the enzyme hexokinase. Hexokinase catalyzes the phosphorylation of glucose to glucose 6-phosphate in the first step of glycolysis.
What are example of enzymes regulated by feed back?
Glucokinase is the enzyme responsible for phosphorylation of glucose in the first step of glycolysis. The glucokinase complex is modified by two different molecules: citrate and ATP. Citrate and ATP are both products of the sequence of reactions in aerobic respiration and are consequently products of glycolysis. As these two molecules' concentrations in the cell build up, they bind to the allosteric site of glucokinase and shut it down.
where is glucokinase active intracellularly?
in the cytosol
What is the glucose sensor in B-cells Why?
glucokinase. glucokinase has a high km(low affinity for glucose) so glucokinase only phosphorylates glucose when blood glucose is high, such as after a meal. As such, it makes sense that this would be sensor for B-cells
Which has a higher affinity for glucose: hexokinase or glucokinase?
Hexokinase
What happens if you have a glucokinase deficiency?
You can't produce insulin
