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The following is the most straightforward all-Canadian route:

After crossing the Canso Causeway, follow the Trans-Canada Highway through Nova Scotia and New Brunswick to Autoroute 20 in Québec at Rivière-du-Loup. Then follow Autoroute 20 west along the south shore of the St Lawrence River, through Montréal, and to the border with Ontario. Québec's Autoroute 20 becomes Ontario's Highway 401 (otherwise known as the Macdonald-Cartier Freeway), which you can follow straight into Toronto.

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Q: Which route would take you from Cape Breton to Toronto?
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