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Why acetic anhydride used instead of acetic acid to prepare aspirin?
Wiki User
∙ 11y ago
The -OH in acetic acid is not a very good leaving group so converting it to an ester is more complicated unlike acetic anhydride which is easier to do so.
Wiki User
∙ 11y ago
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In the preparation of aspirin water is added to the reaction flask Why?
The formation of aspirin will proceed faster if acetic anhydride is used in place of acetic acid. However, acetic anhydride will hydrolyze in the presence of water to form acetic acid, slowing down the reaction.
What percent salicylic acid in aspirin?
37.16% is the expected yield in the reaction of salicylic acid and acetic anhydride used to form aspirin.
How can we react dehydrating agent with acetic acid?
Dehydration of acetic acid to prepare acetic anhydride occur at 8oo oC.
Mechanism of aspirin synthesis?
Aspirin is generally produced by the following mechanism (starting from basic materials) Phenol --(NaOH, CO2, heat)--> Sodium Salicylate (+para isomer) --(H2SO4)--> Salicylic acid --(acetic anhydride)--> acetylsalicylic acid (Aspirin) Due to the myriad of organic reactions, there are multiple possibilities at each stage. However, the above is the most efficient and common way of synthesizing Aspirin. For example, the last reaction (esterification) may be accomplished by using an acyl halide instead of an anhydride (e.g. ethanoyl/acetic chloride instead of acetic anhydride). However, the acyl halide is more costly to synthesize and more unstable to handle.
In the aspirin synthesis excess acetic anhydride is hydrolyzed by the addition of water which converts the anhydride into acetic acid Write the balanced equation for this reaction?
The reaction is: (CH3CO)2O + H2O = 2 CH3COOH
What chemicals are needed to produce aspirin?
Salycylic acid and acetic anhydride with a sulphuric acid catalyst
What is the process of making aspirin?
Aspirin is made when salicylic acid and acetic anhydride is reacted in the presence of an acid catalyst such as H2SO4. Acetylsalicylic acid (aspirin) and acetic acid is formed. The reaction is an esterification reaction.
What are the impurity in aspirin synthesis?
The main impurties are probably the unreacted reactants. i.e salicylic acid and some acetic anhydride (ethanoic anhydride)
What would happen if the sulfuric acid was left out in the reaction between acetic anhydride and salicylic acid to prepare acetylsalicylic acid?
Because Salicylic Acid reacts with Acetic Anhydride in the presence of H2SO4 and CH3COOH to give Aspirin. The sulphuric acid does not react. If you measure the volume/weight of the acid before the reaction and after the reaction, there will be no change. Note:-You can also use Acetyl Chloride in the presence of phosphoric acid instead on Acetic Anhydride.
What is the compound of aspirin?
The active medical ingredient in Aspirin is acetylsalicylic acid, or A.S.A.
How do you prepare trifluoroperacetic acid?
by urea hydrogen peroxide reaction with tri fluro acetic anhydride
How do you know which OH group on salicylic acid reacts to form aspirin?
Aspirin is formed in a reaction between salicylic acid and acetic anhydride. In this reaction it is the phenolic alcohol group that reacts to form the aspirin.
