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Why do two daughters of a hemophilia father no carry the gene?
Wiki User
∙ 11y ago
There are a few ways this could happen.
1) First, if the father has Acquired Hemophilia, it is not genetic and thus would not be passed to his daughters.
2) Adoption - A father only passes the genes to his daughters if they were in fact conceived with his DNA. (obviously there are other ways that daughters may not have been conceived by the father that raises them, but I;ll leave those to your imagination)
3) While being almost impossible (similar odds to being struck by lightening 5 separate times and surviving all 5) a random mutation could in theory correct the existing mutation.
4) Assuming the father has genetic hemophilia and was the sperm donar for the daughters in question, it is actually likely that the tests were wrong. Often females can test erroneously negative for being carriers until their early to mid 20s.
Wiki User
∙ 11y ago
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A woman is a carrier for hemophilia what are the chances for sons with hemophilia if the father does not have hemophilia?
Since the gene for Hemophilia is carried on the X chromosome and males pass only their Y chromosome onto their sons, no their sons should not have hemophilia. Of course all daughters of a male with hemophilia will be carriers of the mutation since they with receive his X chromosome, not the Y.
Does a human offspring inherit hemophilia from the mother or father?
Hemophilia is sex linked. Males inherit from their mother, daughters are carriers if the defective gene is inherited from one of either parent. A female must inherit two copies of the defective allele to have hemophilia .
Can a male be a carrier for hemophilia?
The gene for hemophilia is found on the 'X' human chromosome. However it is a recessive gene so if a woman (who has two 'XX' chromosomes) has one bad 'X' and one good 'X' she will not have hemophilia but will be a carrier .If she has female children and their father is not a hemophiliac, then half of her daughters may carry the bad 'X' chromosome but non will manifest the disease.However, if her children are male then her sons will have an 'X' chromosome inherited from her and a 'Y' chromosome inherited form the father and there is a 50% chance that the 'X' chromosome inherited will be the bad one. If the son inherits the bad 'X' he will be a hemophiliac and if he lives to father any daughters then all these daughters will be hemophilia carriers (because they must inherit his (bad) 'X' chromosome).It is possible for a woman to manifest hemophilia if the mother is a carrier and the father is a hemophiliac. In this case it is possible for a daughter to inherit the bad 'X' from the father and the mother's bad 'X' giving the daughter two bad 'X' chromosomes.
What chromosomes has been determined to carry this gene in hemophilia?
the X chromosome
In a family with parents who do not have hemophilia one son has hemophilia. Who was the carrier of the gene for hemophilia?
First of all, Spontaneous mutations account for 1/3 of the cases of genetic hemophilia. This means that 1 out of 3 people born with hemophilia have no family history of the trait prior to that person. In the scenario you are describing, you are assuming that there was a carrier when in fact, there is a good chance that there was not. There is also a chance that the child born with hemophilia received the mutation from his mother. Frequently women will have the mutation on one X chromosome but not their second. Depending od the individual case, the mother could carry the gene but not be symptomatic. It is impossible for the son to have received the gene from his father. Since in order for a boy to actually be a boy, he must receive his father's Y chromosome and not his X chromosome, a son cannot receive the affected X chromosome from his father. Also, in order for a father to pass the trait on through daughters, the father himself would be a hemophiliac.
Did Stacy Romanov and her sisters have hemophilia?
Grand Duchess ANASTASIA and her sisters were probably carriers of the hemophilia gene but did not suffer from the effects of hemophilia. Males suffer from hemophilia. In rare cases girls do suffer but that is only when both parents carry the mutated gene
If you know a woman has hemophilia what can you infer about her parents genetype?
Her father has to have hemophilia as well, and the mother is a carrier or also has hemophilia. So if we pretend that the hemophilia gene is "x", you need to have "xx" to have hemophilia. The father must have the genotype "Yx" and the mother has the have "Xx" or "xx".
If a female carrier for hemophilia mates with a healthy male who doesn't have hemophilia what are the expected genotypes and phenotypes of their children?
Haemophilia is a recessive, X-based disorder. The woman in your question is a carrier, meaning she has the defective gene, but isn't bothered by it. Therefor, the woman is of the type 'Xx'. The man is of the type 'XY', not carrying the defective gene. Their children can then be: XX, xX, XY, xY. This means that their daughters won't be affected by it, but might carry it, and their sons either not carry it at all, or carry it and be haemophilic.
What person is credited with introducing the gene for hemophilia into the royal families of Europe?
Queen Victoria of England who reigned from 1837 - 1901 was the first of the royals to carry the gene.
Did Queen Victoria married a man with hemophilliac?
No, Queen Victoria's husband Prince Albert was not a hemophiliac. Hemophilia is a sex linked gene carried on the X Chromosome. If Prince Albert had been a hemophiliac than his sons could not of had hemophilia and all of his daughters would have been carriers. This was not the case however. One of Victoria and Albert's sons had hemophilia and two of their daughters passed the gene on. This means that it was Queen Victoria herself that passed it on, not Albert.
How did Queen Victoria cause hemophilia in royalty of Europe?
NO one is sure of exactly how Queen Victoria got the gene for hemophilia since per presumed father Duke Edward of Kent was not a hemophiliac and researchers looked into her family history and did not find anything. Victoria probaby received it from a mutation. It did not just end with her thought. Two of her daughters and a son passed the gene on to their descendants. The descendants spread the disease from Russia, Spain and Germany through marriage.
How is hemophilia inherited?
Hemophilia is carried on the X chromosome. If hemophilia is inherited by a son (1/3 of the cases are spontaneous mutations and not inherited) the gene was passed to him from the mother. If hemophilia is inherited by a daughter the gene could have come from either the mother, father or even both. (if from the father, he himself would have been a hemophiliac) A male only has one X chromosome so if the one he has has the gene for hemophilia he is a hemophiliac. The trait is considered recessive however incomplete dominance is know to occur frequently leading to the trait to at least partially be shown in females with a mutation on only one of their X chromosomes. When this occurs, women can demonstrate the symptoms and have low clotting factor levels similar to their male counterparts. A female with the genes for hemophilia on both X chromosomes will undoubtably have hemophilia as well.
