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Will the protein coded by the mutated strand of DNA function differently from the original strand?
Wiki User
∙ 13y ago
It depends on the particular mutation. Some are "silent" which means the substitution of a base actually codes for the same amino acid as the previous. In this case, the sequence and function of the polypeptide is exactly the same.
If the mutation is a nonsense or missense mutation however, then the structure and function of the protein is indeed affected. A nonsense mutation results in a codon becoming a "stop" codon, thereby terminating the polypeptide prematurely. Such proteins are nonfunctional. Missense mutations result in the change in sequence of amino acids; one amino acid takes the place of another due to the changed codon. These proteins can also be non-functional, but sometimes they can function, albeit less efficiently.
Wiki User
∙ 13y ago
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What is muteins?
protein that is a product of expression of a gene that was mutated.
How can mutation in gene lead to a new trait in an organism?
The mutated gene codes for a protein that cause a new trait
Is Hemophilia mutated allele that produces a defective form of the protein hemoglobin?
False; Hemophilia is caused by a mutated allele that produces a defective form of the protein fibrin.Sickle Cell Disease is caused by a defective form of hemoglobin.
How does the sequence of DNA affect the function of a protein?
The sequence of nucleotides in DNA molecule is equivalent and is closely related to an amino acid sequence in the protein molecule. If for any reason the sequence of DNA nucleotides changes it will be reflected in amino acid sequence in the protein. Moreover, the correct sequence of amino acid in the protein will form the correct three-dimensional structure, or tertiary structure, that will confer the biological activity to protein. If a wrong amino acid is translated from a mutated gene in the DNA could change the spatial structure of the protein and therefore modify or erase its biological function.
What is the Folding of proteins?
Protein folding determines the shape of the protein, and thus what it does, because it is the shape of the protein which enables it to perform its function. For example, enzymes need to have exactly the right shape to fit with the molecules they are working with to catalyze them. Also, hemoglobin is specifically folded with four pocket like areas to allow oxygen to attach to it. The shape of the protein is specific to the function that it is performing, and is different for each protein. If there is even a slight change in the make up of the protein, or a mutation (the amino acids are messed up) then the protein will fold differently. Even a slight change in the composition of the protein can disable the protein from properly performing the function which it is meant to do.
What is muteins?
protein that is a product of expression of a gene that was mutated.
How can mutation in gene lead to a new trait in an organism?
The mutated gene codes for a protein that cause a new trait
Is Hemophilia mutated allele that produces a defective form of the protein hemoglobin?
False; Hemophilia is caused by a mutated allele that produces a defective form of the protein fibrin.Sickle Cell Disease is caused by a defective form of hemoglobin.
Why can missenes mutations not have an effect on protein function?
Say the part of the gene that is mutated does not change the amino acid sequence of the protein made through the mRNA; hydrophobic amino acid stays hydrophobic. We have many of these small nucleotide polymorphisms in our genomes and they are useful trackers of human migrations, for instance.
What does recessive tell us about gene's expression?
Recessive doesn't really describe the expression of a gene. When a gene is "expressed" a protein is made. Recessive describes what form of the gene is expressed or in other words, which allele. A recessive protein may look different and function differently than a dominant protein. This is oversimplified though because there are many different interactions and mechanisms that determine protein function.
How does the sequence of DNA affect the function of a protein?
The sequence of nucleotides in DNA molecule is equivalent and is closely related to an amino acid sequence in the protein molecule. If for any reason the sequence of DNA nucleotides changes it will be reflected in amino acid sequence in the protein. Moreover, the correct sequence of amino acid in the protein will form the correct three-dimensional structure, or tertiary structure, that will confer the biological activity to protein. If a wrong amino acid is translated from a mutated gene in the DNA could change the spatial structure of the protein and therefore modify or erase its biological function.
What is the Folding of proteins?
Protein folding determines the shape of the protein, and thus what it does, because it is the shape of the protein which enables it to perform its function. For example, enzymes need to have exactly the right shape to fit with the molecules they are working with to catalyze them. Also, hemoglobin is specifically folded with four pocket like areas to allow oxygen to attach to it. The shape of the protein is specific to the function that it is performing, and is different for each protein. If there is even a slight change in the make up of the protein, or a mutation (the amino acids are messed up) then the protein will fold differently. Even a slight change in the composition of the protein can disable the protein from properly performing the function which it is meant to do.
What is the function Heat shock protein?
function Heat shock protein
Is caused by a mutated allele that produces a defective form of the protein hemoglobin.?
False, Sickle Cell Disease :))
What happened to a protein that has become denatured?
A protein is denatured because of high temperatures or changes in pH. When it is denatured, it means that the protein has lost its original shape and therefore, it cannot function properly anymore.
How might protein synthesis execute differently if a mutation occurs?
Mutant protein will form.
Why does a denature protein no longer function normally?
the function of each protein is a consequence of its specific shape, which is lost when a protein becomes denatured.The shape of a protein determines its specific function within a cell. Denaturing a protein will alter its shape, thus it will no longer function.
