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Agranulocytosis means a failure of the bone marrow to make enough white blood cells (neutrophils). Bone marrow is the soft tissue inside bones that helps form blood cells.
Alternative NamesGranulocytopenia; Granulopenia; Neutropenia
Causes, incidence, and risk factorsAgranulocytosis is one cause of a person not having enough of a specific type of white blood cells, called neutrophils or granulocytes.
A low neutrophil count (neutropenia) may also occur when white blood cells are destroyed faster than they can be produced.
SymptomsPersons with this condition are more likely to develop infections.
Signs and testsSee: Blood differential test
Wiki User
∙ 13y ago
Agranulocytosis is a severe condition characterized by a dangerously low level of white blood cells, specifically granulocytes. This places individuals at high risk for infections which can become life-threatening. Common causes include certain medications, autoimmune diseases, and viral infections. Treatment involves addressing the underlying cause and supportive care to prevent infections.
Wiki User
∙ 12y agoAgranulocytosis means a failure of the bone marrow to make enough white blood cells (neutrophils). Bone marrow is the soft tissue inside bones that helps form blood cells.
Alternative NamesGranulocytopenia; Granulopenia
Causes, incidence, and risk factorsAgranulocytosis may be caused by:
- Certain bone marrow diseases such as myelodysplasia
- Chemotherapy and bone marrow transplantation
Agranulocytosis results in a person not having enough of a specific type of white blood cells, called neutrophils or granulocytes. A low neutrophil count (neutropenia) may also occur when white blood cells are destroyed faster than they can be produced.
SymptomsPersons with this condition are more likely to develop infections.
Signs and testsSee: Blood differential test
ReferencesBagby GC. Leukopenia and leukocytosis. In Goldman L, Ausiello D, eds. Cecil Medicine. 23rd ed. Philadelphia, Pa: Saunders Elsevier; 2007: chap 173.
Reviewed ByReview Date: 09/06/2010
David C. Dugdale, III, MD, Professor of Medicine, Division of General Medicine, Department of Medicine, University of Washington School of Medicine; James R. Mason, MD, Oncologist, Director, Blood and Marrow Transplantation Program and Stem Cell Processing Lab, Scripps Clinic, Torrey Pines, California. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.
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What antipsychotic drug may be associated with agranulocytosis?
Agranulocytosis has been associated with clozapine. This is a potentially fatal reaction, but can be prevented with careful monitoring of the white blood count.
What it is agranulocytosis?
Lower than normal levels of a type of white blood cells called neutrophils/granulocytes.
What is agranulocytosis?
An acute condition marked by severe depression of the bone marrow, which produces white blood cells, and by prostration, chills, swollen neck, and sore throat sometimes with local ulceration.
What is the meaning of lymphocytes granulocytopenia?
Granulocytopenia-- A condition characterized by a deficiency of white blood cells.
What has the author Suzanne Leah Iverson written?
Suzanne Leah Iverson has written: 'In vitro and in vivo investigations into idiosyncratic drug reactions: the role of reactive metabolites produced by the target tissue in terbinafine-induced cholestatic hepatitis and antipsychotic-induced agranulocytosis'
What precautions should be taken with atypical antipsychotic drugs?
Although the atypical antipsychotics are generally safe, clozapine has been associated with severe agranulocytosis, a shortage of white blood cells.
What are the properties of mefenamic acid?
> CNS:headache, dizziness, somnolence, fatigue, tiredness, tinnitus, ophthalmic effects> Dermatologic:rash, pruritis, sweating, dry mucous membrane, stomatitis> GI:nausea, dyspepsia, GI pain, diarrhea, vomiting, constipation, flatulence> GU:Dysuria, renal impairment> Hematologic:bleeding, platelet inhibition with higher doses, neutropenia, eosinophilia, leukopenia, pancytopenia, thrombocytopenia, agranulocytosis, granulocytopenia, aplastic anemia, decreased Hgb or Hct, bone marrow depression, menorrhagia> Respiratory:dyspnea, hemoptysis, pharyngitis, bronchospasm, rhinitis>Other:peripheral edema, anaphylactoid reactions to anaphylactic shock
Why cant you lay in a tanning bed while taking sulfamethoxazole tmp?
This is a combination of Sulfamethoxazole with Trimethoprim used to treat bacterial infections.About 10 % patients areallergicto it. (Sulfa drug.) So with so many better alternative antimicrobial drugs in hand, doctors avoid using this combination. Apart from drug induced rash, 'which mayaggravatein sun light', patient can have many reactions, though rare, like Agranulocytosis, Steven Johnson syndrome,Erythemamultiform e, Exfoliative dermatitis. So better avoid this drug above 5 years and below six months of age.
The granulocyte percent in your complete blood count is high what does this mean?
The normal range for granulocyte percentage is 45.5 - 79.7%, which translates into a normal granulocyte count of 2.2 - 8.8 x 10^3/uL. Granulocytopenia is an abnormally low concentration of granulocytes in the blood. This condition reduces the body's resistance to many infections. Closely-related terms include agranulocytosis (no granulocytes at all) and neutropenia (deficiency of neutrophil granulocytes). Transfusion of granulocytes would have been a solution to the problem. However, granulocytes live only ~10 hours in the circulation (for days in spleen or other tissue), which gives a very short-lasting effect. In addition, there are many complications of such a procedure. If you have a high percentage be happy!!!cheers
What are side effects of Sultamicillin?
This is the dtailed description of side effects of sultamicillin nLocal (injection): Pain at injection site and thrombophlebitis in IV administration. nGastrointestinal system: Stomatitis, tongue discoloration, gastritis, diarrhea, enterocolitis, pseudomembranous colitis. nSkin and soft tissue: Skin rash, itching, urticaria, erythema multiforme and rarely, exfoliative dermatitis and some hypersentivity reactions. nHematological: Agranulocytosis and decreases in hemoglobin, hematocrit, erythrocyte, leucocyte, lymphocyte and platelet or increases in lymphocyte, monocyte, eosinophilia and platelet; these findings are reversible and return to normal upon discontinuation of therapy. nLaboratory findings: Increases in SGOT, SGPT, LDH, alkaline phosphatase, BUN and serum creatinine and decreases in serum albumin and total protein. Erythrocyte and hyaline casts can be seen in urine.
Does sulfameth work for strep throat infections?
It is sometimes a choice doctors will use to treat strep if drugs such as the Z Pak have not yielded results. Ideally you need to have a throat culture taken to determine whether it is a bacterial or viral infection. Antibiotics won't cure a viral sore throat; time will.
Is metaxalone 800 mg a narcotic?
Firstly i would like to mention that metamizol is illegal in Canada and the United States as far as i know. Secondly although it is considered a Non-steroidal anti-inflammatory drug it does give you an euphoric feeling, it is also a powerful pain killer much like ketorolac (brand name Toradol). I have used both of these drugs and i find that they do have an abuse potential, i highly doubt that people can become dependent on these drugs since there is absolutely no withdrawal. Finally if you are looking for something to stop moderate to severe pain these drugs are a great substitute to opiates, if you have stumbled upon this topic trying to figure out if this drug will get you high, yes it will give you a minor high.Metamizol can be purchased in Europe the brand name is Analgin, the specific countries selling this drug that i know of is Ukraine and Russia, there is no problem carrying it over the border even though it is illegal in Canada and the States.Metamizol does not belong to the group of non steroidal anti inflammatory drugs (NSAID) but to the non-opioid analgetics, being an cyclooxigenase-inhibitor, therefore being antipyretic, analgetic, spasmolytic and antiphlogistic. IT is not an narcotic drug. and in contrast to the NSAID's it does not cause stomach problems.it does not cause depdendency or addiction and any kind and a hig' is not one of the discribed sideeffects.the prohibition is due to its sideeffect of an agranulocytosis (1 out of 1.1 million) with at times fatal outcome. if used correctly fatalities occure in 25 out of 100 million wich is significantly less then in aspirin or diclofenac.
