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In molecular Biology and genetics, mutations are changes in a genomic sequence: the DNA sequence of a cell's genome or the DNA or RNA sequence of a virus. They can be defined as sudden and spontaneous changes in the cell. Mutations are caused by radiation, viruses, transpositions and mutagen chemicals, as well as errors that occur during meiosis or DNA replication.[1][2][3] They can also be induced by the organism itself, by cellular processes such as hyper mutation.
Mutation can result in several different types of change in sequences;(DNA) these can either have no effect, alter the product of a gene, or prevent the gene from functioning properly or completely. Studies in the fly Philosophic melanoma suggest that if a mutation changes a protein produced by a gene, this will probably be harmful, with about 70 percent of these mutations having damaging effects, and the remainder being either neutral or weakly beneficial.[4] Due to the damaging effects that mutations can have on genes, organisms have mechanisms such as DNA repair to remove mutations.[1]
Therefore, the optimal mutation rate for a species is a trade-off between costs of a high mutation rate, such as deleterious mutations, and the metabolic costs of maintaining systems to reduce the mutation rate, such as DNA repair enzymes.[5] Viruses that use RNA as their genetic material have rapid mutation rates,[6] which can be an advantage since these viruses will evolve constantly and rapidly, and thus evade the defensive responses of e.g. the human immune system.[7]
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What causes mutations during the process of protein synthesis?
Mutations during protein synthesis can be caused by errors in DNA replication, exposure to mutagens like radiation or chemicals, or spontaneous changes in the genetic code. These mutations can alter the sequence of amino acids in a protein, potentially affecting its structure and function.
How can mutations affect protein synthesis in cells What is the result?
Mutations can result in changes to the DNA sequence, leading to changes in the mRNA sequence during transcription. This can cause changes in the amino acid sequence during translation, potentially altering the structure and function of the resulting protein. The result can be a dysfunctional or altered protein, affecting the cell's ability to carry out its normal functions.
Why can missenes mutations not have an effect on protein function?
Say the part of the gene that is mutated does not change the amino acid sequence of the protein made through the mRNA; hydrophobic amino acid stays hydrophobic. We have many of these small nucleotide polymorphisms in our genomes and they are useful trackers of human migrations, for instance.
What term is defined as a change in the DNA structure of a cell in which the instructions for making a particular protein are affected?
A mutation is defined as a change in the DNA structure of a cell in which the instructions for making a particular protein are affected. Mutations can lead to altered protein production, which may result in changes in cellular function or contribute to genetic disorders.
Why do some kinds of point mutations cause greater changes in proteins than others?
Because not every point mutation changes the protein. If it doesn't change, we call it a silent mutation or when one letter is deleted at the beginning, than the whole chain changes, but if it's at the end only the and changes so it's a bigger effect on the protein :p
Mutations that cause dramatic changes in protein structure are often?
Mutations that cause dramatic changes in protein structure are often deleterious and can lead to dysfunctional or nonfunctional proteins. These mutations can disrupt the overall folding, stability, and function of the protein, resulting in a loss of its normal biological activity or causing harmful effects on the organism.
What causes mutations during the process of protein synthesis?
Mutations during protein synthesis can be caused by errors in DNA replication, exposure to mutagens like radiation or chemicals, or spontaneous changes in the genetic code. These mutations can alter the sequence of amino acids in a protein, potentially affecting its structure and function.
How can mutations affect protein synthesis in cells What is the result?
Mutations can result in changes to the DNA sequence, leading to changes in the mRNA sequence during transcription. This can cause changes in the amino acid sequence during translation, potentially altering the structure and function of the resulting protein. The result can be a dysfunctional or altered protein, affecting the cell's ability to carry out its normal functions.
What are examples of mutations and describe the consequences?
Examples of mutations include point mutations (substitution, insertion, deletion), chromosomal mutations (duplication, deletion, inversion, translocation), and silent mutations. These mutations can lead to various consequences such as changes in protein structure and function, genetic disorders, and cancer.
Will cells with mutations always make normal proteins?
Cells with mutations may not always produce normal proteins. Mutations can alter the DNA sequence, which may result in changes to the structure or function of the protein produced. These changes can lead to abnormal protein function, which can impact cellular processes and potentially contribute to disease.
Why can missenes mutations not have an effect on protein function?
Say the part of the gene that is mutated does not change the amino acid sequence of the protein made through the mRNA; hydrophobic amino acid stays hydrophobic. We have many of these small nucleotide polymorphisms in our genomes and they are useful trackers of human migrations, for instance.
How does a mutation change the events at the ribosome?
Mutations can alter the sequence of amino acids in a protein, which can affect the protein's structure and function. This can impact the protein's ability to interact with the ribosome and other molecules involved in protein synthesis, potentially leading to changes in the efficiency or accuracy of protein production.
What term is defined as a change in the DNA structure of a cell in which the instructions for making a particular protein are affected?
A mutation is defined as a change in the DNA structure of a cell in which the instructions for making a particular protein are affected. Mutations can lead to altered protein production, which may result in changes in cellular function or contribute to genetic disorders.
Why do some kinds of point mutations cause greater changes in proteins than others?
Because not every point mutation changes the protein. If it doesn't change, we call it a silent mutation or when one letter is deleted at the beginning, than the whole chain changes, but if it's at the end only the and changes so it's a bigger effect on the protein :p
How a mutation during replication can affect a protein that is synthesized?
A mutation during replication can lead to changes in the DNA sequence, which can consequently result in changes in the amino acid sequence of the corresponding protein. These changes can alter the protein's structure, function, or stability, ultimately affecting its overall biological activity. Depending on the nature and location of the mutation, the protein may exhibit loss of function, gain of function, or be unaffected.
How do frameshift mutations impact the structure and function of proteins?
Frameshift mutations occur when nucleotides are inserted or deleted from a gene sequence, causing a shift in the reading frame during protein synthesis. This results in a completely different amino acid sequence being produced, leading to a non-functional or altered protein structure. As a result, frameshift mutations can significantly impact the structure and function of proteins, potentially causing genetic disorders or diseases.
How can mutation in DNA affect what proteins are made by the cell?
Mutations in DNA can lead to changes in the sequence of amino acids in a protein, affecting its structure and function. This can result in altered protein function, loss of function, or gain of new function, impacting cellular processes and potentially leading to diseases.
