From Webster's Dictionary:
thalidomide
; Main Entry: : tha·lid·o·mide ; Pronunciation: : \thə-ˈli-də-ˌmīd, -məd\ ; Function: : noun ; Etymology: : phthalic acid + -id- (from imide) + -o-+ imide ; Date: : 1958 : a drug C13H10N2O4 that was formerly used as a sedative and is now used as an immunomodulatory agent especially in the treatment of leprosy and that is known to cause malformations of infants born to mothers using it during pregnancy
Credit: Merriam-Webster's Online Dictionary
Thalidomide was prescribed for morning sickness in pregnancy before the devastating effects were known. Thalidomide affects angiogenesis which is the process in which new blood vessels form. By preventing the formation of these new vessels to take place, directly resulting in babies being born with no limbs.
It might cause Birth defects in women who are pregnant or women who might get pregnant in the future. It has caused really bad birth defects in the past, and it would probably do so in the future if women who are capable of bearing children are exposed to it.
A new concept that is tested in a scientific investigation is known as a hypothesis. This is a proposed explanation for a phenomenon that can be tested through experiments or observations to determine its validity.
"Dermatologically tested" means the product has been evaluated by dermatologists to ensure it is safe for use on the skin. This testing helps determine the likelihood of any adverse reaction or irritation when the product is applied.
Not necessarily. The offspring being alike and resembling the organism being tested is an indication of the parent being homozygous for the traits being tested, but it is not a definitive proof. Further tests or observations would be needed to confirm the parent's genotype.
Thalidomide all went wrong because it wasn't tested properly and they skipped some vital tests before it was used on actual patients.
An autopsy can reveal signs of Thalidomide overdose, such as the presence of the drug in the person's system or physical symptoms of toxicity. Blood and tissue samples can be tested for Thalidomide levels to confirm an overdose. Additionally, the person's medical history and any prescriptions they were taking can provide clues to potential overdoses.
They tested the drug on animals, which was not a very good thing to do research wise either way, but on top of that, they didn't test it on pregnant animals.
The chemical formula of thalidomide is C13H10N2O4.
It increased the awareness of the need to look at safety profiles closer, especially in pregnant women and children (or fetuses).
It increased the awareness of the need to look at safety profiles closer, especially in pregnant women and children (or fetuses).
Thalidomide was supposed to be an effective sedative for pregnant women, but thalidomide caused birth defects and peripheral neuropathy.
Dark Remedy: The Impact of Thalidomide and Its Revival as a Vital Medicine by Rock Brynner and Trent D. Stephens Suffer the Children: The Story of Thalidomide Tough Cookie: The Less Than Virtuous Tale of a Thalidomide Mum by Sheila Mottley Thalidomide and the Power of the Drug Companies (A Penguin special) by Robert Nilsson and Henning Sjostrom Dark Remedy: The Impact of Thalidomide and Its Revival as a Vital Medicineby Rock Brynner and Trent D. Stephens Suffer the Children: The Story of Thalidomide Tough Cookie: The Less Than Virtuous Tale of a Thalidomide Mum by Sheila Mottley Thalidomide and the Power of the Drug Companies (A Penguin special) by Robert Nilsson and Henning Sjostrom
Thalidomide regulates the immune response by suppressing a protein, tumor necrosis factor alpha.
I only know of one so far, and it is Thalidomide. It caused serious birth defects in the babies of the pregnant women who took this drug.
Dr.R.Kunz and Dr.H.Keller invented thalidomide in Germany
The cast of Happy Birthday Thalidomide - 2004 includes: Mat Fraser