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Mode of action of pepsin

Updated: 8/9/2023
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13y ago

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Pepsin, a bovine gastric mucosa enzyme, cleaves peptide bonds of polypeptides specifically to the amino side when the amino acid is a Leucine, Phenylalanine, Tryptophan, or Tyrosine, but not if the terminal carboxyl of the previous amino acid, of the peptide bond to be cleaved, is a Proline.

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7y ago
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13y ago

Pepsin cleaves proteins preferentially at carboxylic groups of aromatic amino acids such as phenylalanine and tyrosine. It will not cleave at bonds containing valine, alanine or glycine.

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