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Is the Pacific Yew an endangered species?
The Pacific Yew (Taxus brevifolia) is not currently listed as an endangered species. However, its populations are at risk due to over-harvesting for its bark, which contains the compound used to make the cancer drug Taxol. Conservation efforts are in place to protect and manage Pacific Yew populations.
In animal cells taxol an anti-cancer drug binds to microtubules and accelerates their assembly stopping mitosis so what in the cell cycle does taxol affect?
Taxol binds to ß-tubulin to promote microtubule assembly and it stabilises the microtubules and messes up the equilibrium between tubulin and microtubule. A cell with stable microtubules proceeds to programmed cell death without dividing. Nathalie Narraidoo University of Nottingham
Does Taxol inhibit the process of cell division by destroying the membrane bound organelles of a cell?
No, Taxol works by binding to microtubules in the cell, stabilizing them and preventing their disassembly. This disrupts the normal process of cell division by inhibiting the mitotic spindle formation, which ultimately leads to cell death. It does not directly destroy membrane-bound organelles.
Why did scientists begin studying the bark of the Pacific yew tree?
The use of the Pacific Yew as a modern medicine dates back to the late 1950's and in the early 1960's research was begun on its cancer fighting properties. During this time there was pressure for serious cancer research and the National Cancer Institute (NCI) was formed. One of their agendas was to look for all medicinal plants that could help in the newly declared war against cancer. The NCI contracted the U.S. Department of Agriculture to find samples of many plant species for research. Taxus brevifolia, the Pacific Yew, was used by the Tsimshian tribe of native Americans as a cancer treatment plant. The Bella Coola tribe used it as a pulmonary aid. The Chehalis tribe - as an infusion to induce perspiring and a general health tonic. The Cowlitz tribe applied the ground plant to heal wounds. The Haihais tribe - used as gastrointestinal aid. The Hanaksiala, Karok and Kitasoo tribes, used it as a urinary aid. The Klallam, Mendocino Indian, Okanagan-Colville, Quinault, Swinomish, Thompson and Yurok tribes all used this tree as an herbal remedy. Source: p.551 "Native American Ethnobotany" by Daniel E. Moerman.
What inhibits the depolymerization of microtubules?
Drugs like taxol inhibit microtubule depolymerization by stabilizing the microtubules and preventing them from disassembling. Additionally, proteins like stathmin bind to tubulin dimers and promote microtubule depolymerization, so inhibiting their activity can also prevent depolymerization.
Where is the drug Taxol is now made?
The place where taxol is now made is Germany. It was originally made from the Pacific yew but later was made synthetically.
What is the original source of taxol?
Pacific yews, it is a very slow growing tree.
What Philippine plant contains taxol?
Taxol is a chemical substance derived from a yew tree of the pacific coast.
What is a chemical in pacific yew tree bark that has cancer fighting properties?
taxol
What does natural taxol come from?
Taxol, also known as paclitaxel, is a chemotherapy medication derived from the Pacific yew tree (Taxus brevifolia). It is extracted from the bark of the tree.
What chemical makes the Pacific Yew Tree resistant to diseases and insects?
Taxol, a chemical compound found in the bark of the Pacific Yew Tree (Taxus brevifolia), is responsible for its resistance to diseases and insects. Taxol has been found to possess antifungal and insecticidal properties, making the tree less susceptible to certain pests and pathogens.
What are chemical processes used to make taxol?
Two processes exist:- extraction from bark of the Pacific yew tree- biosynthesis
Where was taxol discovered?
Taxol was first discovered in Taxus brevifolia Nutt in 1971.
What phylum was taxol originally found?
Confirerophyta is the phylum where taxol was originally found.
Where was taxol first discoved?
Taxol was first discovered in Taxus brevifolia Nutt in 1971.
The plant that produces taxol a chemical with cancer-fighting properties?
Taxol was primarily isolated from the bark of the Pacific Yew or Western Yew tree, Taxus brevifolia.Taxus brevifolia is a conifer native to the Pacific Northwest of North America. It ranges from southernmost Alaska south to central California, mostly in the Pacific Coast Ranges, but with an isolated disjunct population in southeast British Columbia, most notably occurring on Zuckerberg Island near Castlegar and south to central Idaho
How many functional groups are there in Taxol?
There are several functional groups in Taxol, including ester, benzene ring, hydroxyl, and amide groups.
