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Nitration of aniline with nitrating mixture gives m-nitro-aniline?
In the nitration of aniline with a nitrating mixture, the electrophilic attack of the nitronium ion occurs at the ortho and para positions due to the activating effect of the amino group. The major product obtained is m-nitroaniline due to steric hindrance that prevents substitution at the ortho position.
Why is not recommended to obtain para -bromoacetanilide by bromination of aniline then acetylation?
Aniline is a benzene with an amine group attached to it. When you brominate aniline, since aniline is electron donating, it directs other substituents to the ortho and para positions. Therefore you will not only get para-bromoacetanilide. However if you just want para-bromoacetanilide, you should go through acetylation first because this changes the amine group on the aniline into an acetamido group which is very bulky and big, and also electron donating. Since it is so big, the bromine cant attach to the ortho positions because of the steric hindrance caused by the very bulky acetamido group and therefore you will get para-bromoacetanilide as your product.
Why the electrophilic substitution reaction of haloarenes is oRtho and pera directing?
Because the +R effect of the haloarene, tends to oppose the -I effect, and hence the deactivation is lesser at the ortho and para positions, compared to any other position (like the meta position). So they tend to be o-p directing.
Why ortho chlorobenzoic acid is stronger than benzoic acid?
Ortho chlorobenzoic acid is stronger than benzoic acid due to the electron-withdrawing effect of the chlorine atom. This increases the acidity of ortho chlorobenzoic acid by stabilizing the conjugate base through delocalization of the negative charge. In contrast, benzoic acid has no such electron-withdrawing substituent.
What is the chemical formula of aniline hydrochloride?
The formula of aniline is C6H7N and the formula of ethanol is C2H5OH.
Nitration of aniline with nitrating mixture gives m-nitro-aniline?
In the nitration of aniline with a nitrating mixture, the electrophilic attack of the nitronium ion occurs at the ortho and para positions due to the activating effect of the amino group. The major product obtained is m-nitroaniline due to steric hindrance that prevents substitution at the ortho position.
Why is not recommended to obtain para -bromoacetanilide by bromination of aniline then acetylation?
Aniline is a benzene with an amine group attached to it. When you brominate aniline, since aniline is electron donating, it directs other substituents to the ortho and para positions. Therefore you will not only get para-bromoacetanilide. However if you just want para-bromoacetanilide, you should go through acetylation first because this changes the amine group on the aniline into an acetamido group which is very bulky and big, and also electron donating. Since it is so big, the bromine cant attach to the ortho positions because of the steric hindrance caused by the very bulky acetamido group and therefore you will get para-bromoacetanilide as your product.
Ortho effect on acidity of carboxylic acid?
The ortho effect refers to the decrease in acidity of a carboxylic acid when bulky substituents are present at the ortho positions of the phenyl ring. This is due to the steric hindrance caused by the bulky groups, which makes it more difficult for the carboxylate anion to be stabilized, resulting in lower acidity.
Why direct halogenation of aniline is not possible?
Well, darling, the reason direct halogenation of aniline is a big no-no is because aniline is a strong activating group that will make the halogenation reaction go haywire and give you a messy mixture of products. Plus, the lone pair on the nitrogen atom in aniline will coordinate with the halogenating agent, making it more selective towards other positions on the ring. So, in a nutshell, direct halogenation of aniline is a recipe for disaster in the lab.
What is ortho evra?
Ortho Evra is a birth control patch that is stuck to your skin. It has the same mode of action and mostly the same side effect profile as the birth control pill.
What is the difference between Aniline Point and Mixed Aniline Point?
There is no any such difference between Aniline point and mixed Aniline point . . . . .
Why the electrophilic substitution reaction of haloarenes is oRtho and pera directing?
Because the +R effect of the haloarene, tends to oppose the -I effect, and hence the deactivation is lesser at the ortho and para positions, compared to any other position (like the meta position). So they tend to be o-p directing.
Why ortho chlorobenzoic acid is stronger than benzoic acid?
Ortho chlorobenzoic acid is stronger than benzoic acid due to the electron-withdrawing effect of the chlorine atom. This increases the acidity of ortho chlorobenzoic acid by stabilizing the conjugate base through delocalization of the negative charge. In contrast, benzoic acid has no such electron-withdrawing substituent.
What is the chemical formula of aniline hydrochloride?
The formula of aniline is C6H7N and the formula of ethanol is C2H5OH.
How do you convert aniline into 246 tribromoanaline?
To convert aniline into 2,4,6-tribromoaniline, you can employ bromination using bromine in the presence of a suitable solvent, such as acetic acid or carbon tetrachloride. Aniline's amino group (–NH2) is an activating and ortho/para-directing group, facilitating the substitution of bromine at the 2, 4, and 6 positions on the aromatic ring. Typically, bromination is done in a controlled manner to ensure multiple substitutions occur, leading to the desired tribromo product. After the reaction, purification methods such as recrystallization can be used to isolate 2,4,6-tribromoaniline.
What brand of birth control pills have ortho tricyclen?
Ortho Tricyclen is made by Ortho.
Why does aniline when subjected to nitration conditions followed by a basic work up form the meta nitroanline and not ortho or para?
It reacts with the acidic conditions (since the NH2 is basic) to form the meta-directing electron withdrawing group NH3. This forms the meta-nitroaniline.
