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Glucose-6-phosphate dehydrogenase catalyzes the first step of the pentose phosphate pathway by converting glucose-6-phosphate to 6-phosphoglucono-δ-lactone, producing NADPH in the process. NADPH is essential for reductive biosynthesis and is a key antioxidant in protecting cells from oxidative stress. Deficiency in G6PD can lead to hemolytic anemia due to decreased antioxidant capacity in red blood cells.

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1y ago

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