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If you are just weighing the container before and after, then yes, the two numbers will not be equal. Mixing sodium bicarbonate (baking soda) and acetic acid (vinegar) liberates carbon dioxide gas, which can't be weighed by a scale. What you must do is subtract the weight after the reaction from the weight before the reaction, and divide it by 46.01, which is the molar mass, in grams, of CO2. That will give you the moles of CO2 generated by the reaction.

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