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Because fructose is processed mostly in the liver, not by insulin produced by the pancreas. The GI index is the glucose index, which measures how much insulin the pancreas must secrete in order to process a given food. Since fructose is a basic sugar, it does not need to be broken down with much insulin, but is instead largely filtered out of the system by the liver. However, a fructose-heavy or fructose-only diet can cause too much stress and potentially cause damage to your liver, an organ you can't live without. So even though fructose has a low GI, it too should be used in moderation to prevent undue stress on the liver.

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