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One gram of protein has 4 grams of calories. By definition of a calorie, it is a unit of heat that determines the amount of energy that foods will produce in the human body. (In 1824, Nicolas Clement discovered that a calorie was a unit of heat)

In a dictionary, a calorie would be defined as "approximates the energy needed to increase the temperature of 1 gram of waterby 1 °C. This is about 4.2 joules."- wikipedia. This is the general definition of a calorie that you would also find in Biology textbooks.

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