What are you talking about?
de qué hablas = what are you talking about
Of which or of what.
Are you talking about me?
Translation: This is indeed the photo that [unknown word - lad] that I want you speak. 'Unknown word(s) perhaps 'de la que' (about which), in which case it reads: 'This is indeed the photo about which I want you to speak'
"De que" would be "Of what" in English.
But from what city
"De quien" means from who?; "De quien(?)-whose(?)";
Sí, puedo hablar un poco de español. ¿En qué puedo ayudarte?
'¿De que te ries?' means 'What are you laughing at?' or 'What's so funny?'
how was your weekend?
What kind of exercises do you do?
It means, "What is there [that's] good?"