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Queen Catherine of Aragon, the first wife of Henry VIII, died on January 7, 1536. Her death is believed to have been caused by cancer, specifically a form of uterine cancer, though some historical accounts also suggest Heart disease or complications related to her long-standing health issues. Catherine had suffered from various ailments in her later years, which contributed to her declining health. Her passing had significant political implications, as it ultimately paved the way for Henry VIII's marriage to Anne Boleyn.

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