Mutations not only change the DNA, but a change to the DNA will change the mRNA. This explains why a mutation in one generation can be passed on to the next generation.
A mutation in a DNA nucleotide sequence would be more harmful than a mutation in a mRNA nucleotide sequence because it could cause the synthesis of multiple nonfunctional proteins in comparison to a mutation in a mRNA nucleotide sequence that would be less harmful because it would result in a few nonfunctional proteins.
DNA mutation can lead to changes in the mRNA sequence due to alterations in the base pairs of the DNA that are transcribed into mRNA. These changes can result in the production of a faulty mRNA molecule, which can affect the translation process and ultimately lead to the production of abnormal or dysfunctional proteins.
The correct sequence of events for a mutation to affect the traits expressed by a cell is as follows: first, the mutation changes the DNA sequence of a gene. Next, this altered DNA is transcribed into messenger RNA (mRNA). Then, the mRNA is translated into a protein. Finally, the change in the protein can lead to a modified phenotype or trait expressed by the cell.
If there is a mutation in the 5' UTR no change in the protein function and abundance will happen.
Yes, a mutation can occur without affecting the phenotype at all. For example, a point mutation may change a nucleotide in a codon, but sometimes, the codon can still code the same amino acid, so the mRNA strand can still make the same protein.
The type of mutation that stops the translation of a protein is a nonsense mutation. This occurs when a base substitution (point mutation) results in a STOP codon and thus stops translation of the sequence into a protein.
The bases of mRNA coded for by a DNA segment are complementary to the original DNA sequence. If the DNA sequences are ATCG, the corresponding mRNA bases will be UAGC.
a serious mutation in ribosomal RNA gene is worse. the mutated ribosomes may lose their abilty to bind to messenger RNAs through Shine Dalgarno Sequences. they may also present wrongly placed E,P and A sites to the messenger RNA. this will lead to lethal results ranging from abnormal polypeptide formation to no formation at all.
The codon UGU codes for the amino acid Cysteine. The codon UGG codes for the amino acid Tryptophan. Therefore the mutation will cause the amino acid Cysteine to be replaced with Tryptophan. These amino acids are quite different, and the final shape of the protein could be changed as a result. This could affect the function of the protein.
a change in the mRNA makes a mutation of the DNA
A mutation does not affect an organism trait for a reason. It is neutral which depends on the environment.
It will affect protein synthesis. mRNA uses DNA (a gene) as a template and mRNA is a template to join amino acids together. If the DNA sequence (gene) is changed, the mRNA will be changed, and the polypeptides will be changed - usually with harmful consequences. Proteins produce phenotypes in organisms, so a mutation in DNA causes abnormalities.