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How does Lipitor work?
It inhibits the rate-limiting enzyme (HMG-CoA reductase) in the multi-step pathway of cholesterol synthesis, in the liver.
Is rate limiting step and regulatory step same?
The rate-limiting step and the regulatory step are related concepts in metabolic pathways, but they are not the same. The rate-limiting step is the slowest reaction in a pathway, which determines the overall rate of the process. In contrast, a regulatory step refers to any step in a pathway that can be modulated by various factors, such as enzymes, allosteric regulators, or feedback mechanisms. While the rate-limiting step is often a regulatory step, not all regulatory steps are rate-limiting.
What is the rate-limiting step of an enzyme-catalyzed reaction?
The rate-limiting step of an enzyme-catalyzed reaction is the slowest step in the reaction that determines the overall rate at which the reaction proceeds.
What does ACTH stimulate?
ACTH stimulates lipoprotein uptake into cortical cells. This increases the bio-availability of cholesterol in the cells of the adrenal cortex.ACTH increases the transport of cholesterol into the mitochondria and activates its hydrolysis.ACTH Stimulates cholesterol side-chain cleavage enzyme, which makes the rate-limiting step in steroidogenesis. This results in the production of pregnenolone.
What stimulates acth?
ACTH stimulates lipoprotein uptake into cortical cells. This increases the bio-availability of cholesterol in the cells of the adrenal cortex.ACTH increases the transport of cholesterol into the mitochondria and activates its hydrolysis.ACTH Stimulates cholesterol side-chain cleavage enzyme, which makes the rate-limiting step in steroidogenesis. This results in the production of pregnenolone.
What is the function of HGM-CoA?
HMG-CoA reductase is an enzyme that catalyzes the rate-limiting step in cholesterol biosynthesis. It converts HMG-CoA to mevalonate, which is a key intermediate in the synthesis of cholesterol and other important molecules in the body. Inhibitors of HMG-CoA reductase are commonly used as cholesterol-lowering medications.
Which enzyme catalyzes the rate-limiting step of glycolysis?
Phosphofructokinase (PFK)
Which of the following enzymes catalyzes the rate-limiting step of glycolysis?
Phosphofructokinase
How does simvastatin work in 70 year old male patient who has post coronary angiography bypass graft with elevated LDL?
Statins are lipid lowering agents specifically a HMG-CoA reductase inhibitor that , inhibits the rate-limiting step in cholesterol biosynthesis by competitively inhibiting HMG-CoA reductase therefore lowering the synthesis of cholesterol in the liver since cholesterol is a major determinant in atherosclerosis.
What is a rate-limiting enzyme?
A rate-limiting enzyme is an enzyme that catalyzes a crucial step in a metabolic pathway and determines the overall rate of that pathway. It usually operates at a slower pace compared to other enzymes in the same pathway, making it the bottleneck for the flow of metabolites. By regulating the activity of this enzyme, cells can control the production of various end products, ensuring metabolic balance and efficiency. Examples include HMG-CoA reductase in cholesterol synthesis and phosphofructokinase in glycolysis.
How do statins improve cholesterol?
Statins are medications that lower blood pressure. They are able to block the action of a chemical in the liver that makes cholesterol. By lowering the cholesterol in the body, your blood pressure is lowered.
What is the significance of the rate-limiting step of the Calvin Cycle in photosynthesis?
The rate-limiting step of the Calvin Cycle in photosynthesis is significant because it controls the overall speed at which the cycle can produce glucose, which is essential for plant growth and energy storage. If this step is slow, it can limit the plant's ability to efficiently convert carbon dioxide into sugars, impacting its overall productivity.
