It's the Generic name for the Brand name Adriamycin, an intravenous cancer drug.
Doxorubicin has a solubility of 10mg in 1 ml of water, which should be warmed slightly.
Intravenous
hyaluronidase
Doxorubicin can induce changes in DNA methylation patterns by affecting the activity of DNA methyltransferase enzymes. It can lead to global hypomethylation or hypermethylation of specific gene promoters, influencing gene expression and potentially contributing to its cytotoxic effects.
yes
Doxorubicin, an anticancer drug.
Doxorubicin is fatal to a cell primarily because it intercalates into DNA, disrupting the normal function of the genetic material and inhibiting DNA replication and transcription. This leads to the formation of free radicals that cause oxidative damage to cellular components, including membranes and proteins. Additionally, doxorubicin can trigger apoptosis, or programmed cell death, as a response to the extensive DNA damage and cellular stress it induces. These mechanisms collectively contribute to its effectiveness as a chemotherapeutic agent but also underscore its cytotoxic nature.
cyclophosphamide (Cytoxan), doxorubicin (Adriamycin), and vincristine (Oncovin), or etoposide and cisplatin.
Heidi Traunecker has written: 'The biology of drug resistance in human sarcoma cells following a brief exposure to doxorubicin'
MOPP (either mechlorethamine or methotrexate with Oncovin, procarbazine, prednisone) and ABVD (Adriamycin or doxorubicin, bleomycin, vincristine, dacarbazine).
At present, a chemotherapeutic regime designated CHOP includes the anti-cancer drugs cyclophosphamide, doxorubicin, vincristine, and prednisone.
Appears to increase the effects of doxorubicin, a cancer medication. Relatively few interactions between rosemary and Western pharmaceuticals have been reported.