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Skeletal muscle:

(occurs at neuro muscular junction)

At the end of the skeletal muscle fibre, there is a single motor neuron that forms many finer branches. At the end of these branches is a synaptic terminal which contain mitochondria and vesicles which in turn contain ACh.

So, when an action potential is propagated down towards the synaptic terminal, ACh is triggered to be released by exocytosis into the synaptic cleft and then onto the motor end plate (which is the other surface upon which the action potential will propagate; this is highly folded for increased surface area).

ACh then binds to receptors on the motor end plate, changing its permeability to Na+ ions. Na+ ions (due to an increased electrochemical gradient) rush into the sarcolemma. This influx increases until AChE breaks down the ACh. This influx results in the generation of an action potential!

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