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Alpha thalassemia was first identified in the 1950s by a group of researchers, including Dr. Thomas C. Chiu and Dr. William A. C. Wong, who studied the genetic basis of the disorder in affected families. The condition is linked to mutations in the HBA1 and HBA2 genes that affect hemoglobin production. While no single individual is credited with "discovering" alpha thalassemia, it was through collaborative research in the field of hematology and genetics that the condition was characterized and understood.
What else can I help you with?
Can minor thalassemia carrier and alpha marry?
Yes, A "carrier" of alpha thalassemia and of beta thalassemia can marry, but not to someone with any hemoglobinopathy. Prof. Kornfeld Pal
What chromosome is thalassemia carried on?
Thalassemia is carried on chromosome 11 and chromosome 16, depending on the type. The alpha-thalassemia gene is located on chromosome 16, while the beta-thalassemia gene is found on chromosome 11. Mutations in these genes affect the production of hemoglobin, leading to the various forms of thalassemia.
Are there other names for Thalassemia disease?
Alpha thalassemia silent carrierAlpha thalassemia minor, also called alpha thalassemia traitHemoglobin H diseaseAlpha thalassemia major, also called hydrops fetalisBeta thalassemia minor, also called beta thalassemia traitBeta thalassemia intermediaBeta thalassemia major, also called Cooley's anemia or beta-zero (ß0) thalassemiaBeta-plus (ß+) thalassemiaMediterranean anemia
Can thalassemia carrier and alpha marry?
yes
What is classification of Thalassemia?
Thalassemia is classified mainly into two types: alpha thalassemia and beta thalassemia, based on which globin chain is affected. Alpha thalassemia occurs due to mutations in the alpha-globin genes, while beta thalassemia results from mutations in the beta-globin genes. Each type can further be categorized into various subtypes based on the severity of the condition, such as thalassemia minor (trait) and thalassemia major (Cooley's anemia). The classification helps determine the appropriate management and treatment strategies for affected individuals.
Will the child be free from thalassemia if you are alpha and father is beta thalassemia trait?
have seen one of my friends sister had kid and all normal no complications...not thalassemia either.........beta and alpha i think there is 25% normal chance
What are the chances of hydrops fetalis recurring if only the mother has alpha thalassemia trait?
It is unlikely.
Where did the different types of Alpha- Thalassemia in the population come from?
Different types of Alpha-Thalassemia in the population primarily arose from genetic mutations in the HBA1 and HBA2 genes responsible for producing alpha-globin chains in hemoglobin. These mutations are believed to have originated in regions where malaria was prevalent, as carriers of the disease often had a selective survival advantage. Over time, these mutations spread through various populations, leading to the different forms of Alpha-Thalassemia observed today. The global distribution reflects historical migration patterns and local adaptation to environmental pressures.
Can you have both alpha thalassemia and beta thalassemia?
Of coare yes. You can get any hemoglobinopathy from a parent without any connection to other hemoglobinopathy (or any other hereditary disease) from the other parent. Prof. Kornfeld Pal
Is thalassemia a sex linked gene?
No, thalassemia is not a sex-linked genetic disorder; it is an autosomal recessive condition. This means that it is caused by mutations in genes located on non-sex chromosomes, specifically the alpha or beta globin genes. Both males and females can be carriers and affected by thalassemia equally, regardless of their sex.
What does thallassemia mean?
Thalassemia describes a group of inherited disorders characterized by reduced or absent amounts of hemoglobin, the oxygen-carrying protein inside the red blood cells. There are two basic groups of thalassemia disorders: alpha thalassemia and beta thalassemia. These conditions cause varying degrees of anemia, which can range from insignificant to life threatening. Go to: http://medical-dictionary.thefreedictionary.com/Thallassemia
What is HbH disease?
Normal Red Blood cells are made up of 2 alpha and 2 beta protein chains.In alpha thalassemia, there's a qualitative decrease in the number of red blood cells (RBC) that have these 2alpha and 2 beta.Since the Alpha protein is made up of 2 genes on Chromosome 16,there are 4 possible alleles.So there's 4 type of Genotypes. 1) A-/AA 2) AA/-- or A-/A- 3) A-/-- 4) --/-- HBH refers to the type of Haemoglobin found in 3) A-/-- in alpha thalassemia whereby 3 out of 4 of the allele is lost due to a deletion mutation on chr 16.
