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Low serotonin levels, for one. Drugs such as fluoxetine, sertraline, paroxetine, citalopram and escitalopram are called SSRI's--Selective Serotonin Reuptake Inhibitors and keep your serotonin levels at normal levels.

Also, low norepinephrine levels can be a problem. Drugs such as venlafaxine, desvenlafaxine and duloxetine are called SNRI's --Serotonin Norepinephrine Reuptake Inhibitors, and help to keep both your serotonin and norepinephrine levels at normal levels.

Dopamine is one the chemical messagers responsible for the "pleasure seeking" behaviors of humans. Low concentrations of dopamine, norepinephrine and serotonin, which controls the emotions of "drive" and daily activities, may not be at the normal levels needed for optimum mental health. These neurotransmitters conduct chemical reactions between "lock & key" type of neuroreceptors. Once the fit is perfect (as in effective amounts of chemicals transmitted), mood and behavior improve.
Mental depression is believed to be related to the low activity of one or more neurotransmitters in the brain.Although it is not understood exactly how most SSRIs work, they are designed to increase the level of serotonin in the brain.

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