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Galen, a prominent Greek physician in the Roman Empire, developed the theory of the four humors, which posited that human health and temperament are influenced by the balance of four bodily fluids: blood, phlegm, yellow bile, and black bile. This theory suggested that an imbalance among these humors could lead to physical and mental illness. Galen's work combined observational studies and philosophical ideas, significantly influencing medical practices for centuries until the advent of modern medicine.

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