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How many genes are there for the four polypeptides in haemoglobin?
Human hemoglobin consists of four polypeptide chains: two alpha (α) and two beta (β) chains. The genes responsible for these chains are HBA1 and HBA2 for the alpha chains, and HBB for the beta chains. Therefore, there are three genes associated with the four polypeptides in hemoglobin.
How does sickel hemoglobin differ from normal hemoglobin?
6th amino acid is changed in haemoglobin chain due to a recessive mutation on beta haemoglobin producing gene
What mutations does beta-thalassemia have on DNA?
Beta-thalassemia is typically caused by mutations in the HBB gene located on chromosome 11. Common mutations include point mutations, deletions, or insertions in the HBB gene, leading to reduced or absent production of beta-globin chains in hemoglobin. These mutations disrupt the normal structure and function of hemoglobin, resulting in anemia and other symptoms associated with beta-thalassemia.
What is the advantage of using the protein sequence from the hemoglobin beta gene to prepare the comparisons between species?
Using the protein sequence from the hemoglobin beta gene for comparisons between species is advantageous because this gene is highly conserved across many vertebrates, reflecting its essential role in oxygen transport. Such conservation allows researchers to identify evolutionary relationships and functional similarities. Additionally, variations in the sequence can provide insights into adaptive changes in response to different environmental pressures. This makes hemoglobin beta a valuable marker for studying evolutionary biology and genetics.
What type of secondary structure does hemoglobin have?
Hemoglobin is a protein with a combination of secondary structures, predominantly consisting of alpha helices and beta sheets. These structural elements help maintain the shape and function of hemoglobin as a globular protein.
Hemoglobin S differs from hemoglobin A in that?
glutamic acid is replaced by valine in the beta chain
What is Fetal hemoglobin?
Fetal hemoglobin has a pair of gamma-globin molecules in place of the typical beta-globins of adult hemoglobin
What is Hemoglobin S?
Hemoglobin produced in association with the sickle cell trait; the beta-globin molecules of hemoglobin S are defective.
Can paper shield beta particles?
Beta particles are not stopped by a paper sheet.
What is the Life span for hemoglobin SC disease or hemoglobin S beta thalassemia?
4 months
How is hemoglobin constructed?
Normal adult hemoglobin has a pair each of alpha-globin and beta-globin molecules
What are the key differences between a parallel beta sheet and an antiparallel beta sheet in protein structure?
In a parallel beta sheet, the strands run in the same direction, while in an antiparallel beta sheet, the strands run in opposite directions. This affects the hydrogen bonding pattern and overall stability of the protein structure.
How many arginine are in a human hemoglobin?
Human hemoglobin consists of four subunits, each containing a heme group and a globin chain. In the adult form of hemoglobin (HbA), there are a total of 8 arginine residues across the alpha and beta chains. Specifically, there are 4 arginine residues in each alpha and beta chain combined, which contributes to the overall structure and function of the protein.
Can person that have hemoglobin e trait marry with a beta thalassemia carrier?
Yes, a person with hemoglobin E trait can marry a beta thalassemia carrier. However, it is important for both individuals to undergo genetic counseling to understand the potential risks for their children. They could have offspring with various combinations of hemoglobin disorders, including hemoglobin E disease or beta thalassemia. Genetic testing can help assess the likelihood of these outcomes.
How can you prevent beta particles?
Thin sheet or plastic may prevent beta particles.
How many globin molecules are in each hemoglobin?
There are four nearly-identical individual protein chains in hemoglobin.
How many genes are there for the four polypeptides in haemoglobin?
Human hemoglobin consists of four polypeptide chains: two alpha (α) and two beta (β) chains. The genes responsible for these chains are HBA1 and HBA2 for the alpha chains, and HBB for the beta chains. Therefore, there are three genes associated with the four polypeptides in hemoglobin.
