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sometime nothing- If the substituted amino acid (AA) is chemically similar (in terms of polarity, acid/base, size) to the original, the protein might be able to function without problem.
However, if the substitution is to a very different AA, then drastic changes can occur. If the wrong AA is sequenced, then the protein might misfold (improper tertiary structure, tertiary structure is determined by primary structure- sequence of AA). If you get a misfolded protein, it might not function as well or at all.
Note that Sickle Cell Disease is caused by a Valine-Glutamine substitution. This results is a misfolded hemoglobin that causes the RBCs to "sickle". Thus, this reduces their oxygen carrying capacity.
What else can I help you with?
When a nitrogenous base is inserted or delete how does that affect the amino acid sequence?
The amino acid sequence is shifted, and this kind of mutation is called a frame shift mutation. All of the amino acid sequence after the mutation will be changed, which will cause a change in shape of the protein, which will then probably result in a nonfunctional protein, since the shape of a protein determines its function.
What is primary structure of a protein and what causes it?
Primary structure of the protein is simply its amino acid sequence. It is the sequence in which amino acids are added during protein synthesis.
The sequence of nucleotides in DNA specifies the sequence of what in a protein?
The sequence of nucleotides in DNA specifies the sequence of amino acids in a protein. Each set of three nucleotides, called a codon, corresponds to a specific amino acid or a signal to start or stop protein synthesis.
What is the Primary level of a protein structure?
The primary level of protein structure refers to the linear sequence of amino acids in a protein chain. It is the simplest level of protein structure and is determined by the specific order of amino acids encoded by the DNA sequence.
How does one protein differ from another protein?
Proteins differ from each other in their amino acid sequence, which is determined by the genetic code. This unique sequence gives each protein its specific structure and function. Differences in amino acid sequence can result in proteins with varying functions, sizes, shapes, and interactions.
When a nitrogenous base is inserted or delete how does that affect the amino acid sequence?
The amino acid sequence is shifted, and this kind of mutation is called a frame shift mutation. All of the amino acid sequence after the mutation will be changed, which will cause a change in shape of the protein, which will then probably result in a nonfunctional protein, since the shape of a protein determines its function.
What determines the amino acid sequence in a protein?
The sequence of amino acids in a protein is determined by the sequence of nucleotides in the mRNA, and this is determined by the sequence of nucleotide bases in the DNA.
What is the order of amino acids in a protein?
The order of amino acids in a protein is determined by the sequence of nucleotides in the gene that codes for that protein. This sequence is transcribed into messenger RNA (mRNA) and then translated into a specific sequence of amino acids during protein synthesis.
What influences protein shape that determines protein function?
Amino acid sequence primarily determines a proteins shape, but secondary (alpha helix and beta sheet) and tertiary structures (Hydrogen bonding, other chemical bonding between structures) adds to it.
Which structure determines the sequence of the building blocks in a protein?
DNA determines the sequence of the amino acids (building blocks) in a protein. The sequence of nitrogen bases in the DNA determines the sequence of amino acids in a protein.
What is primary structure of a protein and what causes it?
Primary structure of the protein is simply its amino acid sequence. It is the sequence in which amino acids are added during protein synthesis.
What is directly responsible for the sequence of amino acids in a protein?
The sequence of amino acids in a protein is directly determined by the sequence of nucleotides in the gene that codes for that protein. This process occurs during protein synthesis, where the genetic information is transcribed from DNA to mRNA and then translated into a specific sequence of amino acids.
The sequence of nucleotides in DNA specifies the sequence of what in a protein?
The sequence of nucleotides in DNA specifies the sequence of amino acids in a protein. Each set of three nucleotides, called a codon, corresponds to a specific amino acid or a signal to start or stop protein synthesis.
What parts of a chromosome specify the amino acid sequence of a protein?
The gene within a chromosome contains the specific sequence of nucleotides that codes for the amino acid sequence of a protein. This gene is transcribed into messenger RNA (mRNA), which is then translated into a specific sequence of amino acids during protein synthesis.
The sequence of amino acids joined together refers to the?
Peptide sequence or amino acid sequence is the order in which amino acid residues, connected by peptide bonds, lie in the chain in peptides and proteins. The sequence is generally reported from the N-terminal end containing free amino group to the C-terminal end containing free carboxyl group. Peptide sequence is often called protein sequence if it represents the primary structure of a protein.
How does amino acid sequence compare?
The amino acid sequence refers to the specific order of amino acids that make up a protein. This sequence determines the protein's structure and function. Changes in the amino acid sequence can alter the protein's properties and may lead to different biological effects.
What is the Primary level of a protein structure?
The primary level of protein structure refers to the linear sequence of amino acids in a protein chain. It is the simplest level of protein structure and is determined by the specific order of amino acids encoded by the DNA sequence.
