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High levels of bilirubin in the blood may be caused by: infection, such as of the gall bladder; inherited diseases, such as Gilbertâ??s syndrome; disease that cause liver damage, such as hepatitis, cirrhosis or mono; and diseases that block the bile ducts such as gall stones or pancreatic cancer. High levels can also be caused by the rapid destruction of red blood cells, such as from sickle cell disease or a reaction to a blood transfusion. Certain medicines can also cause a rise in the levels of bilirubin.

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