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Premarins main constituent is estrone (50%),

Sodium 13-methyl-17-oxo-3-sulfonatooxy-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]-phenanthrene, C18H21O(SO4Na), 372.412 g/mol

So there is 100%*[5*16.0 (g O/mol) / 372.412 (g/mol)] = 21.5% Oxygen in estrone.

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