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- Production involves the use of mice. These mice are used to produce both antibodies and tumour cells. The production of tumour cells involves deliberately inducing cancer in mice. Despite specific guidelines drawn up to minimise any suffering, some people still have reservations about using animals in this way.
- To eliminate the need for humanisation of the antibody, transgenic mice can be used. In this case, a human gene is placed in the mice to that they can produce human antibodies rather than mouse antibodies. This raises the whole debate surrounding the ethics of genetic engineering.
- Monoclonal antibodies have been used successfully to treat a number of diseases, including cancer and Diabetes, saving many lives. There have also been some deaths associated with their use in the treatment of multiple sclerosis.
- Testing for the safety of new drugs presents certain dangers. In march 2006, six healthy volunteers took part in the trial of new monoclonal antibody (TGN1412) in London. Within minutes they suffered multiple organ failure, probably as a result of T cells overproducing chemicals that stimulate an immune response or attacking the body tissues. All the volunteers survived, but it raises issues about the conduct of drug trials.
What else can I help you with?
How do monoclonal antibodies help in controlling plant disease?
how do monoclonal antibodies help controlling plant disease?
What is monoclonal?
Monoclonal-- Genetically engineered antibodies specific for one antigen.
What did Cesar milstein discover?
monoclonal antibodies
What are the key differences between monoclonal antibodies and polyclonal antibodies in terms of their specificity and production methods?
Monoclonal antibodies are highly specific, targeting a single antigen, while polyclonal antibodies can target multiple antigens. Monoclonal antibodies are produced from a single clone of cells, resulting in uniformity, while polyclonal antibodies are produced from multiple clones of cells, leading to variability.
What diseases are being treated with monoclonal antibodies?
Monoclonal antibodies are commonly used to fight a large number of diseases including cancer. The monoclonal antibodies fight the disease by targeting a certain antigen and recruiting the body's natural immune system to destroy the antigen-infected cells.
Are Monoclonal antibodies are not normally found in humans?
yes
What does the medical abbreviation MOABS mean?
Monoclonal Antibodies
What purpose does monoclonal antibodies serve?
To kill things
What are the key differences between fully human monoclonal antibodies and humanized monoclonal antibodies in terms of their effectiveness and potential applications in medical treatments?
Fully human monoclonal antibodies are derived entirely from human sources, making them less likely to cause immune reactions. They are generally more effective and have a lower risk of side effects compared to humanized monoclonal antibodies, which contain some non-human components. Fully human monoclonal antibodies are often preferred for medical treatments due to their higher specificity and reduced risk of adverse reactions.
Monoclonal antibodies re used for diagnosis of juvenile diabetes?
No they can not
What is the recommended method for the production of monoclonal antibodies?
malkat singh
How can one create monoclonal antibodies?
Monoclonal antibodies are created by fusing a specific type of immune cell, called a B cell, with a cancer cell to form a hybrid cell called a hybridoma. This hybridoma cell can then produce large quantities of identical antibodies that target a specific antigen. These monoclonal antibodies can be used for various medical purposes, such as diagnosing and treating diseases.
