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During the Age of Exploration, major cities in Europe were primarily located along Coastlines and navigable rivers, facilitating trade and maritime travel. Key cities included Lisbon in Portugal, which served as a launch point for expeditions, and Seville, a hub for Spanish exploration. Other important cities were Venice, known for its trade routes to Asia, and Amsterdam, which emerged as a commercial center in the late 16th century. These cities played crucial roles in the economic and cultural exchanges that characterized the era.

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