"Well he is an assassin who was an experiment of weapon x and he won't shut up".
I'll keep the above for a general idea. However, I don't think I have the patience to go on and on and on all night about what is WRONG with Deadpool.
Deadpool, aka Wade Winston Wilson became a mercenary for Project X after being dishonorably discharged from Army Special Forces.
He botched a job, and his girlfriend was targeted for it but rescued.
He was diagnosed with brain cancer.
Given his condition, he was recruited into the Weapon X program alongside Garrison Kane, Slayback, and Sluggo.
Weapon X's goal, at the time, was regeneration and invulnerability, nigh invincibility.
The program was a bit of a failure. In fact, Deadpool got his name from a group placing bets on who would die first, a "deadpool".
Long story short, he fell in love with Death (personified, of course), was tortured repeatedly, mercy-killed his best friend, had his heart ripped out (literally), staged a jailbreak, got back in the Merc business, was hired to kill Cable, got his butt kicked by X-Force, helped Siryn fight against her uncle and the Juggernaut, fell in love with her (hopelessly, since she's a smoking hot Scot and he's a walking scab), AND SO ON AND SO FORTH.
You asked what's wrong with Deadpool? What's NOT wrong with him?
The movie Deadpool is about introducing him because in the future there going to make a movie that adds all marvel charactors
In the movie, Wade Wilson (pre-Deadpool) was subject to many kinds of torture which is supposed to give him a mutation. Wade Wilson (pre-Deadpool) got his mutation from being put in a chamber that gives him enough oxygen to breathe but not much oxygen where he feels like he is suffocating.
Deadpool has no steadfast enemy he does repeatedly meet an ex hydra agent named Bob who he frequently injures.