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Oxycodone
Developed in 1916, oxycodone is a medicine used to treat moderate to severe pain. Low dosage of the drug provides temporary relief from diarrhea. Its most common side effects include anxiety, constipation, memory loss, dizziness and dry mouth.
1,898 Questions
Should you take methadone before percocet?
There is no reason you should need to know this unless you are a drug addict and on methadone already. If you are taking methadone, you should not be prescribed percocets. But if you are looking for ways to get higher yes, they work together, just adds to the effects of each other.
Can you mix Demerol and oxycodone 30mg together?
yes you can mix them, but you will not experence nearly the high you would from just the oxycodone alone, the methadone partially blocks the euphoric effect of the oxycodone... speaking from experence save the methadone, and take the oxy.
If you are allowed to take oxycodone if you take a Suboxone in a drug test will you be fine?
yes it is very dngerous to take oxy with subs!! you can die no doubt about it. what suboxin does is prevent you from doin an oxy it is a opiet blocker. if you take a sub and try to do an oxy an hour or so later you dont get high or if you do an oxy and then do a sub you will get severe withdrawl symptoms or go into cardiac arrest be careful with both of these drugs.
Is methadone safe to use to stop addiction of oxycodone?
DO NOT TAKE THE TWO TOGETHER BEFORE YOU TALK TO YOUR DOCTOR! Methadone is a very strong pain reliever and could be fatal if taken with out a doctors supervision.
I currently take 150mg of oxycodone, 160mg of Oxycontin and 30mg of methadone. so yes you can take both. but something to remember you need to take them at the same time or so I have been told, If you do not I have been told one will block the other. Also the methadone attaches it self to a different pain receptor then the Oxycontin or oxycodone so it amplifies the effects ten fold! It in no way blocks anything If taking correctly methadone is used all the time for chronic pain patients like me. it lasts longer then the other medications and offers a different type of pain relief. So when your taking methadone and oxycodone together you're attaching to both sides of the pain receptor. Which gives me almost 100% pain relief.
Medically, you swallow as directed. When I used to abuse them, you snort, smoke and shoot them. Don't recomentd the latter 3, leads to a horrible addiction (as bad as heroin)
Can someone take hydrocodon and Oxycontin togather?
As long as one of them is time released you can take the immediate realease on top pf that.since the time relase is low dose and the immediate is for any break through pain you still have
Can a urine test tell the difference between percocet and hydrocodone?
No, Oxycodone is in Percocet. If you're meaning Oxycontin and Percocet; the answer is still no because Oxycodone is the ingredient in Oxycontin and the same drug used in Percocet. The only difference is that it may show a higher amount of it, just say you took a few extra Percocet You're good either way though. Oxycontin just is a time released capsule with a large amount of Oxycodone(10-80mg/Each) in it and Percocet has a small immediate effective amount of Oxycodone(5-10mg/Each) mixed with APAP ([325-650mg/each] acetaminophen, Tylenol, etc.) in it. Hope that answers you're question pretty well. Have fun ;) and stay safe! -Patrick (Future Pharmaceutical tech)
That is a generic OxyContin. 40mg.
Each pill contains 40mg of pure oxycodone hydrochloride, which is an opioid analgetic.
The medicine should be used with care as it is very addicitive and has a high potential for abuse.
Is it all right to take xanax while on oxycodone?
You should discuss this with your physician. Alprazolam (Xanax) and oxycodone taken together can have significant sedative and respiratory effects. I would avoid taking them together if you have to perform any activities which require you to be awake and alert.
How long does it take percocet to take effect?
I have been prescribed the sub for Percocet which is Oxycodin and it takes about 20 min depending on if your stomach is empty or full.
If you snort oxycodone how long is it detectable in urine screens?
2-4 days...please continue reading
Metabolism and Elimination
A high portion of oxycodone is N-dealkylated to noroxycodone during first-pass metabolism.
Oxymorphone, is formed by the O-demethylation of oxycodone. The metabolism of oxycodone
to oxymorphone is catalyzed by CYP2D6. Free and conjugated noroxycodone, free and
conjugated oxycodone, and oxymorphone are excreted in human urine following a single oral
dose of oxycodone. Approximately 8% to 14% of the dose is excreted as free oxycodone over 24
hours after administration. Following a single, oral dose of oxycodone, the mean ± SD
elimination half-life is 3.51 ± 1.43 hours.
Acetaminophen is metabolized in the liver via cytochrome P450 microsomal enzyme. About
80% to 85% of the acetaminophen in the body is conjugated principally with glucuronic acid and
to a lesser extent with sulfuric acid and cysteine. After hepatic conjugation, 90% to 100% of the
drug is recovered in the urine within the first day.
About 4% of acetaminophen is metabolized via cytochrome P450 oxidase to a toxic metabolite
which is further detoxified by conjugation with glutathione, present in a fixed amount. It is
believed that the toxic metabolite NAPQI (N acetyl-p-benzoquinoneimine, Nacetylimidoquinone)
is responsible for liver necrosis. High doses of acetaminophen may deplete
the glutathione stores so that inactivation of the toxic metabolite is decreased. At high doses, the
capacity of metabolic pathways for conjugation with glucuronic acid and sulfuric acid may be
exceeded, resulting in increased metabolism of acetaminophen by alternate pathways.
Absorption and Distribution - The mean absolute oral bioavailability of oxycodone in cancer
patients was reported to be about 87%. Oxycodone has been shown to be 45% bound to human
plasma proteins in vitro. The volume of distribution after intravenous administration is
211.9 ± 186.6 L.
Absorption of acetaminophen is rapid and almost complete from the GI tract after oral
administration. With overdosage, absorption is complete in 4 hours. Acetaminophen is relatively
uniformly distributed throughout most body fluids. Binding of the drug to plasma proteins is
Oxycodone and Acetaminophen Tablets USP Page 3 of 16
5 mg*/325, 7.5 mg*/325 mg, 7.5 mg*/500 mg Prescribing Information
and 10 mg*/325 mg
variable; only 20% to 50% may be bound at the concentrations encountered during acute
intoxication.
Laboratory Tests
Although oxycodone may cross-react with some drug urine tests, no available studies were found
which determined the duration of detectability of oxycodone in urine drug screens. However,
based on pharmacokinetic data, the approximate duration of detectability for a single dose of
oxycodone is roughly estimated to be one to two days following drug exposure.
Urine testing for opiates may be performed to determine illicit drug use and for medical reasons
such as evaluation of patients with altered states of consciousness or monitoring efficacy of drug
rehabilitation efforts. The preliminary identification of opiates in urine involves the use of an
immunoassay screening and thin-layer chromatography (TLC). Gas chromatography/mass
spectrometry (GC/MS) may be utilized as a third-stage identification step in the medical
investigational sequence for opiate testing after immunoassay and TLC. The identities of 6-keto
opiates (e.g., oxycodone) can further be differentiated by the analysis of their methoximetrimethylsilyl
(MO-TMS) derivative.
Interactions with Alcohol and Drugs of Abuse
Oxycodone may be expected to have additive effects when used in conjunction with alcohol,
other opioids, or illicit drugs that cause central nervous system depression.
OVERDOSAGE
Signs and Symptoms
Serious overdose with oxycodone and acetaminophen tablets is characterized by signs and
symptoms of opioid and acetaminophen overdose. Oxycodone overdosage can be manifested by
respiratory depression (a decrease in respiratory rate and/or tidal volume, Cheyne-Stokes
respiration, cyanosis), extreme somnolence progressing to stupor or coma, skeletal muscle
flaccidity, cold and clammy skin, pupillary constriction (pupils may be dilated in the setting of
hypoxia), and sometimes bradycardia and hypotension. In severe overdosage, apnea, circulatory
collapse, cardiac arrest and death may occur.
In acute acetaminophen overdosage, dose-dependent, potentially fatal hepatic necrosis is the
most serious adverse effect. Renal tubular necrosis, hypoglycemic coma and thrombocytopenia
may also occur.
In adults, hepatic toxicity has rarely been reported with acute overdoses of less than 10
grams and fatalities with less than 15 grams. Plasma acetaminophen levels > 300 mcg/mL at
4 hours post-ingestion were associated with hepatic damage in 90% of patients; minimal
hepatic damage is anticipated if plasma levels at 4 hours are < 120 mcg/mL or < 30 mcg/mL
at 12 hours after ingestion.
Importantly, young children seem to be more resistant than adults to the hepatotoxic effect of an
acetaminophen overdose. Despite this, the measures outlined below should be initiated in any
adult or child suspected of having ingested an acetaminophen overdose.
Early symptoms following a potentially hepatotoxic overdose may include: nausea, vomiting,
diaphoresis and general malaise. Clinical and laboratory evidence of hepatic toxicity may not be
apparent until 48 to 72 hours post-ingestion.
What is stronger hydrocodone apap 7.5-750 or oxycodone 10 mg-325 mg?
Everyone is different , but generally oxycodone is better.
How long do opiate withdrawals last?
Opiate Withdrawls can last from 5 days to 2 months. Dont let the 2 months thing scare you away from quitting these horrible drugs. It all depends on what opiate you were using, how much and for how long. I am on day 4 of a year and a half of vicodin/percocet and the occasional oxy-contins. After day 5 and 6 you start feeling better. I have gone through this before and its just a matter of having strong will power to get you through it
I'm currently in the 6th WEEK of opiate detox (from a 3+ year habit that culminated with me taking as much as 2500mg/day of oxycodone). Although the acute symptoms have faded, I am still constantly experiencing problems, including profuse night sweats, diarrhea, joint/muscle pain, jitters/tremors and a general feeling of malaise. But I fully understand why: it took me 3 years to get to the point where I could tolerate what would surely be a lethal dose of Oxycontin to most everyone else, so naturally it will take some time for my body to recover from that.
Can Oxycontin show up positive while on naltrexone?
Yes Naltrexone has been known to test positive for opiates in almost all at-home drug screens. I was baffled when I tested my daughter, until I called her doctor and confirmed that Naltrexone can indeed cause a false-positive.
Do outdated percocet still work?
Depending on how outdated-it says do not use after a year,but I've been assured by a pharmacist that they can be kept another 6 months or so-just as long as they are not soft and/or falling apart on their own
Does marijuana and percocet show up as the same thing on a drug test?
No. There is no THC in percs. They contain acetaminophen and oxycodone but no THC which is found in marijuana.
Is there penicillin in oxycodone?
yes of course. that is the combo i was prescribed when i got my wisdom teeth out. just make sure you're not allergic to penicillin. as for oxy, if you are prone to headaches or migraines you may have the worst possible migraine of your life when you are coming off of them, as i did. so if you are prone, make sure you slowly taper off them. best of luck. :)
How long does oxycodone stay in system?
I took a drug test for my job after 16 days of taking roxicodone 30s and FAILED for opiates. I was taking 3, 30 mg tabs a day for two weeks and nothing else. 16 days after the last pill, I took a urine test and failed. Therefor, everyone is different as I ahave heard that people have tested clean after only five days. DON'T BET ON IT! Give yourself a month as far as I am concerned to make sure.
If you have codeine allergies will you have Oxycontin allergies?
It's technically possible for someone to exhibit an allergic response (hives, difficulty breathing) to codeine, but have no problem taking oxycodone. That said, the odds are probably against it, and as such should only be attempted at the discretion of a trained medical professional (with OTC antihistamines on-hand, just in case). Molecularly speaking, codeine and oxycodone are very similar. Codeine lacks the hydroxy group at the 14- position, and has a 7-8 double bond. Also, the 6- position of codeine contains an alcohol group instead of a carbonyl.
How long do prescribed sleeping pills stay in you system?
It depends on what is called the half-life of the drug. Short half-life sleeping pills can be metabolized as quickly as 24 hours. Long half-life sleeping pills can take several days to be eliminated.
